Early Fibrinogen Replacement to Treat the Endotheliopathy of Trauma: Novel Resuscitation Strategies in Severe Trauma

The authors provide a comprehensive review of the endothelial glycocalyx, the components that may be targeted to improve clinical outcomes, and the next steps for evaluation in human subjects.

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Bibliographic Details
Published inAnesthesiology (Philadelphia) Vol. 139; no. 5; pp. 675 - 683
Main Authors Douin, David J., Fernandez-Bustamante, Ana
Format Journal Article
LanguageEnglish
Published United States Lippincott Williams & Wilkins 01.11.2023
Subjects
Fibrinogen - therapeutic use
Hemostatics
Humans
Resuscitation
Wounds and Injuries - complications
Wounds and Injuries - therapy
Online AccessGet full text
ISSN0003-3022
1528-1175
1528-1175
DOI10.1097/ALN.0000000000004711

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Summary:The authors provide a comprehensive review of the endothelial glycocalyx, the components that may be targeted to improve clinical outcomes, and the next steps for evaluation in human subjects.
Bibliography:This article is featured in “This Month in Anesthesiology,” page A1. Peter Nagele, M.D., M.Sc., served as Handling Editor for this article. Submitted for publication May 1, 2023. Accepted for publication July 19, 2023. Address correspondence to Dr. Fernandez-Bustamante: University of Colorado School of Medicine, 12401 E. 17th Avenue, B-215, Aurora, Colorado 80045. ana.fernandez-bustamante@cuanschutz.edu. Anesthesiology’s articles are made freely accessible to all readers on www.anesthesiology.org, for personal use only, 6 months from the cover date of the issue.
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Study concept and design: All Authors
Critical revision of the manuscript for important intellectual content: All Authors
Author Contributions
Drafting of the manuscript: All Authors
ISSN:0003-3022
1528-1175
1528-1175
DOI:10.1097/ALN.0000000000004711