DRUG-CARRIER PROPERTY OF ALBUMIN MICROSPHERES IN CHEMOTHERAPY. III. EFFECT OF MICROSPHERE-ENTRAPPED 5-FLUOROURACIL ON EHRLICH ASCITES CARCINOMA IN MICE

To examine the possibility of utilizing albumin microspheres as drug-carriers, an in vitro release of 5-fluorouracil (5-FU) from albumin microspheres was examined and the effect of intraperitoneally injected drug-carrying microspheres on Ehrlich ascites carcinoma in mice was studied. In vitro releas...

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Published inJournal of Pharmacobio-Dynamics Vol. 2; no. 6; pp. 350 - 355
Main Authors SUGIBAYASHI, KENJI, KATO, YOSHIO, MORIMOTO, YASUNORI, NADAI, TANEKAZU, AKIMOTO, MASAYUKI
Format Journal Article
LanguageEnglish
Published The Pharmaceutical Society of Japan 1979
Subjects
tumor cell
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ISSN0386-846X
1881-1353
DOI10.1248/bpb1978.2.350

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Summary:To examine the possibility of utilizing albumin microspheres as drug-carriers, an in vitro release of 5-fluorouracil (5-FU) from albumin microspheres was examined and the effect of intraperitoneally injected drug-carrying microspheres on Ehrlich ascites carcinoma in mice was studied. In vitro release characteristics determined by dialysis experiments showed that 5-FU release continued over one week. We also noted that drug release in the peritoneum of ascites-bearing mice continued over one week and that their life-span increased. Furthermore, the microspheres were phagocytized in vivo by the ascites cells. Our results suggest that albumin microspheres containing 5-FU may represent an effective system of drug delivery with prolonged action.
ISSN:0386-846X
1881-1353
DOI:10.1248/bpb1978.2.350