LCT-13910C > T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy

• Published in: Digestive and liver disease Vol. 42; no. 10; pp. 741 - 743
• Main Authors: Tarabra, Elena, Pazienza, Paola, Borghesio, Elisabetta, Actis, Giovanni C., Tappero, Gianfranco, Framarin, Luciana, Ayoubi, Mohammad, Castellino, Francesca, Leone, Nicola, Sansoè, Giovanni, De Paolis, Paolo, Comandone, Alessandro, Rosina, Floriano
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2010
• Subjects: Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Colorectal cancer; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - etiology; Colorectal Neoplasms - genetics; DNA, Neoplasm - genetics; Female; Gastroenterology and Hepatology; Genotype; Humans; Incidence; Italy - epidemiology; Lactase - genetics; Lactase - metabolism; Lactose intolerance; Lactose Intolerance - complications; Lactose Intolerance - enzymology; Lactose Intolerance - genetics; LCT-13910C > T; Male; Middle Aged; Polymorphism; Polymorphism, Genetic; Prognosis; Retrospective Studies; Risk Factors; Italy; LCT-13910C > T; Lactose intolerance; Colorectal cancer; Polymorphism
• ISSN: 1590-8658; 1878-3562; 1878-3562
• DOI: 10.1016/j.dld.2010.02.013

The activity of epithelial lactase ( LCT) associates with a polymorphism 13910 bp upstream the LCT-encoding gene ( LCT-13910C > T). The relationship between LCT-13910C > T polymorphism and risk for colorectal cancer is unclear. We examined the relationship between the LCT-13910C > T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population. 793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C > T variant by TaqMan real time-PCR. Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR = 1.041; 95% CI = 0.751–1.442; p = 0.868) or polyps (OR = 0.927; 95% CI = 0.630–1.363; p = 0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype. In the Italian population the LCT-13910C > T polymorphism is not associated to the risk for colorectal cancer or polyps.