Diffusion-Weighted Magnetic Resonance Imaging for the Evaluation of Prostate Cancer: Optimal B Value at 3T

• Published in: Korean journal of radiology Vol. 14; no. 1; pp. 61 - 69
• Main Authors: Koo, Ji Hyun, Kim, Chan Kyo, Choi, Dongil, Park, Byung Kwan, Kwon, Ghee Young, Kim, Bohyun
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Radiology 01.01.2013; 대한영상의학회
• Subjects: Aged; Aged, 80 and over; Area Under Curve; Biopsy; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging - methods; Genitourinary; Humans; Localization; Magnetic resonance imaging; Male; Middle Aged; Neoplasm Staging; Patients; Predictive Value of Tests; Prostate cancer; Prostate-Specific Antigen - blood; Prostatectomy; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Quantitative analysis; Retrospective Studies; Sensitivity and Specificity; Work stations; 방사선과학; Netherlands; Prostate neoplasm; Diagnosis; Diffusion-weighted MR imaging; Apparent diffusion coefficient
• ISSN: 1229-6929; 2005-8330; 2005-8330
• DOI: 10.3348/kjr.2013.14.1.61

To retrospectively determine the optimal b value of diffusion-weighted imaging (DWI) for predicting the presence of localized prostate cancer, and to evaluate the utility of DWI under different b values in differentiating between cancers and benign prostatic tissues. Eighty patients with suspected prostate cancer underwent MRI including DWI at 3T, followed by radical prostatectomy. DWI was examined under different b values. Apparent diffusion coefficient (ADC) maps were generated by using b = 0, and other b values of 300, 700, 1000 or 2000 s/mm(2). For predicting the presence of cancers, four different ADC maps were analyzed independently by two blinded readers. ADCs were measured in benign and malignant tissues. For predicting the presence of 110 prostate cancers, the sensitivity and area under the curve (AUC) for an experienced reader was significantly greater at b = 1000 (85% and 0.91) than b = 300, 700 or 2000 s/mm(2) (p < 0.01). For a less-experienced reader, the AUC was significantly greater at b = 700, 1000 or 2000 than b = 300 s/mm(2) (p < 0.01). Mean ADCs of the cancers in sequence from b = 300 to 2000 s/mm(2) were 1.33, 1.03, 0.88 and 0.68 × 10(-3) mm(2)/s, which were significantly lower than those of benign tissues (p < 0.001). The optimal b value for 3T DWI for predicting the presence of prostate cancer may be 1000 s/mm(2).