Microalbuminuria is Independently Associated with Arterial Stiffness and Vascular Inflammation but not with Carotid Intima-Media Thickness in Patients with Newly Diagnosed Type 2 Diabetes or Essential Hypertension

• Published in: Journal of Korean medical science Vol. 28; no. 2; pp. 252 - 260
• Main Authors: Shin, Dong Il, Seung, Ki-Bae, Yoon, Hye Eun, Hwang, Byung-Hee, Seo, Suk Min, Shin, Seok Joon, Kim, Pum-Joon, Chang, Kiyuk, Baek, Sang Hong
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.02.2013; 대한의학회
• Subjects: Albuminuria; Area Under Curve; C-Reactive Protein - analysis; Cardiovascular Diseases - etiology; Carotid Intima-Media Thickness; Creatinine - urine; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - physiopathology; Female; Humans; Hypertension - complications; Hypertension - diagnosis; Hypertension - physiopathology; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Original; Risk Factors; Vascular Stiffness; 의학일반; Inflammation; Albuminuria; Vascular Stiffness; Carotid Intima-Media Thickness
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2013.28.2.252

The association between microalbuminuria (MAU) and the indices of macrovascular complication in patients with newly diagnosed type 2 diabetes (D) or essential hypertension (H) was evaluated. Total 446 patients were classified into four groups according to the urinary albumin-to-creatinine ratio: MAU-D (n = 104), normoalbuminuria (NAU)-D (n = 114), MAU-H (n = 116), and NAU-H (n = 112). The indices of macrovascular complication including arterial stiffness evaluated by pulse-wave-velocity (PWV), carotid intima-media thickness (IMT), and vascular inflammation marked by high-sensitivity C-reactive protein (hsCRP) were assessed. PWV, IMT, and hsCRP were higher in patients with MAU than in those with NAU in both diabetes and hypertension groups. In both MAU-D and MAU-H groups, PWV and hsCRP levels were positively correlated with MAU level (MAU-D: r = 0.47, 0.41, MAU-H: r = 0.36, 0.62, respectively, P < 0.05). Additionally, PWV and hsCRP were independent factors predicting MAU (diabetes group: OR 1.85, 1.54, hypertension group: OR 1.38, 1.51, respectively, P < 0.001), but not IMT. MAU is independently associated with arterial stiffness and vascular inflammation but not with IMT in patients with newly diagnosed type 2 diabetes or essential hypertension, which emphasizes the importance of proactive clinical investigations for atherosclerotic complications in patients with MAU, even in newly diagnosed diabetes or hypertension.