Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy

• Published in: Annals of neurology Vol. 51; no. 5; pp. 641 - 644
• Main Authors: Briellmann, Regula S., Berkovic, Samuel F., Syngeniotis, Ari, King, Mark A., Jackson, Graeme D.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.05.2002; Willey-Liss
• Subjects: Adolescent; Adult; Atrophy; Biological and medical sciences; Epilepsy, Temporal Lobe - pathology; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Hippocampus - pathology; Humans; Longitudinal Studies; Magnetic Resonance Imaging - statistics & numerical data; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Prospective Studies; Regression Analysis; Seizures - pathology; Human; Volumetric analysis; Nervous system diseases; Complex partial epilepsy; Nuclear magnetic resonance imaging; Cerebral disorder; Crisis; Central nervous system disease; Medical imagery; Adult; Temporal lobe epilepsy; Evolution; Morphometry; Hippocampus
• ISSN: 0364-5134; 1531-8249
• DOI: 10.1002/ana.10171

This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, −30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 ± 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans (p = 0.0007, r = 0.6), suggesting seizure‐associated hippocampal damage.