Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk
Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%–70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pre...
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| Published in | Women's health reports (New Rochelle, N.Y.) Vol. 5; no. 1; pp. 319 - 323 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Mary Ann Liebert, Inc., publishers
01.04.2024
Mary Ann Liebert |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2688-4844 2688-4844 |
| DOI | 10.1089/whr.2023.0120 |
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| Abstract | Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%–70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis. |
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| AbstractList | Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%-70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis.Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%-70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis. Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%?70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis. |
| Author | Alvarez Saltos, Jehimy Jean Bonmatí-Santané, Alexandra Piedra Sánchez, Jordi Céspedes López, Roberto Noboa Paez, Cristina Maroto González, Anna Calabia Martínez, Jordi Visa Figueredo, Natalia |
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| Keywords | autologous blood donation anti-PP1Pk p phenotype miscarriage plasmapheresis |
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| Title | Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk |
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