Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk

Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%–70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pre...

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Published inWomen's health reports (New Rochelle, N.Y.) Vol. 5; no. 1; pp. 319 - 323
Main Authors Bonmatí-Santané, Alexandra, Céspedes López, Roberto, Alvarez Saltos, Jehimy Jean, Calabia Martínez, Jordi, Noboa Paez, Cristina, Piedra Sánchez, Jordi, Visa Figueredo, Natalia, Maroto González, Anna
Format Journal Article
LanguageEnglish
Published United States Mary Ann Liebert, Inc., publishers 01.04.2024
Mary Ann Liebert
Subjects
anti-PP1Pk
autologous blood donation
Case Report
miscarriage
p phenotype
plasmapheresis
autologous blood donation
anti-PP1Pk
p phenotype
miscarriage
plasmapheresis
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ISSN2688-4844
2688-4844
DOI10.1089/whr.2023.0120

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Summary:Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%–70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis.
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ISSN:2688-4844
2688-4844
DOI:10.1089/whr.2023.0120