CAMELLIASAPONINS B1, B2, C1 AND C2, NEW TYPE INHIBITORS OF ETHANOL ABSORPTION IN RATS FROM THE SEEDS OF CAMELLIA JAPONICA L

• Published in: Chemical & pharmaceutical bulletin Vol. 42; no. 3; pp. 742 - 744
• Main Authors: HARADA, Emiko, YAMAHARA, Johji, MURAKAMI, Toshiyuki, MATSUDA, Hisashi, YOSHIKAWA, Masayuki, MURAKAMI, Nobutoshi
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1994; Maruzen
• Subjects: acylated oleanene-type triterpene monodesmoside; Alcoholism and acute alcohol poisoning; Animals; Biological and medical sciences; Camellia japonica; camelliasaponin B1; camelliasaponin C1; Depression, Chemical; Drugs, Chinese Herbal - pharmacology; Ethanol - pharmacokinetics; ethanol absorption inhibitor; Intestinal Absorption - drug effects; Medical sciences; Rats; Saponins - chemical synthesis; Saponins - pharmacology; Theaceae; Toxicology; Asia; China; Terpenoid; Antialcohol drug; Seeds; Ethanol; Rat; Pharmacognosy; Rodentia; Medicinal plant; Saponin; Vertebrata; Mammalia; Absorption; Folk medicine; Dicotyledones; Animal; Angiospermae; Camellia japonica; Plant origin; Triterpene; Spermatophyta; Inhibition; Theaceae; Structural analysis
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.42.742

New type inhibitors of ethanol absorption, camelliasaponins B1, B2, C1 and C2, were isolated from the seeds of Camellia japonica L. The structures of camelliasaponins were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effect of camelliasaponins and related saponins on ethanol absorption have been examined, and it was found that the triterpene oligoglycoside structure having an acyl group was essential to exerting the activity.