Effects of enriched branched-chain amino acid supplementation on sarcopenia

To evaluate the effects of short-term administration of enriched branched-chain amino acids (BCAAs) on subjects with pre-sarcopenia or sarcopenia, our quasi-experimental study enrolled 33 subjects (12 pre-sarcopenia/21 sarcopenia; 6 men/27 women; mean age 66.6 ± 10.3 years) to take one sachet (3.6 g...

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Published inAging (Albany, NY.) Vol. 12; no. 14; pp. 15091 - 15103
Main Authors Ko, Chun-Hung, Wu, Shin-Jiuan, Wang, Shan-Tair, Chang, Yin-Fan, Chang, Chin-Sung, Kuan, Ta-Shen, Chuang, Hua-Ying, Chang, Chia-Ming, Chou, Willy, Wu, Chih-Hsing
Format Journal Article
LanguageEnglish
Published United States Impact Journals 26.07.2020
Subjects
Aged
Amino Acids, Branched-Chain - administration & dosage
Dietary Supplements
Duration of Therapy
Female
Hand Strength - physiology
Humans
Male
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiopathology
Research Paper
Sarcopenia - diagnosis
Sarcopenia - diet therapy
Sarcopenia - metabolism
Sarcopenia - physiopathology
Treatment Outcome
Walking Speed - physiology
pre-sarcopenia
nutritional supplements
BCAA
sarcopenia
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ISSN1945-4589
1945-4589
DOI10.18632/aging.103576

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Summary:To evaluate the effects of short-term administration of enriched branched-chain amino acids (BCAAs) on subjects with pre-sarcopenia or sarcopenia, our quasi-experimental study enrolled 33 subjects (12 pre-sarcopenia/21 sarcopenia; 6 men/27 women; mean age 66.6 ± 10.3 years) to take one sachet (3.6 g) of enriched BCAA powder twice a day for five weeks followed by a discontinuation period of 12 weeks. We evaluated sarcopenic parameters, including grip strength, 6-meter gait speed, and bioelectrical-impedance-analysis-derived skeletal mass index (SMI), at baseline, 5 weeks, and 17 weeks. We found that both pre-sarcopenic and sarcopenic subjects showed improved SMI, gait speed, and grip strength at 5 weeks. However, all three parameters progressively declined at 17 weeks, especially SMI and grip strength in subjects aged < 65 years and gait speed and grip strength in subjects aged ≥ 65 years. It thus appears that supplementation with enriched BCAAs for 5 weeks correlates with short-term positive effects on sarcopenic parameters but attenuation of those effects following discontinuation for 12 weeks.
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ISSN:1945-4589
1945-4589
DOI:10.18632/aging.103576