Flow and diffusion of indocyanine green and fluorescein dyes in the fovea centralis

Fluorescein, a diffusible dye, and indocyanine green, a non-diffusible reference substance, were injected into the circulatory system of healthy human subjects with normal ocular functions. A fundus reflectometer simultaneously measured the time course of fluorescence intensity of the fluorescein an...

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Bibliographic Details
Published inExperimental eye research Vol. 24; no. 1; pp. 15 - 23
Main Authors Riva, Charles E., Ben-Sira, Isaac, Feke, Gilbert T.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 1977
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ISSN0014-4835
1096-0007
DOI10.1016/0014-4835(77)90280-9

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Summary:Fluorescein, a diffusible dye, and indocyanine green, a non-diffusible reference substance, were injected into the circulatory system of healthy human subjects with normal ocular functions. A fundus reflectometer simultaneously measured the time course of fluorescence intensity of the fluorescein and the infrared absorption of indocyanine green in the fovea centralis. The fluorescein curve represents both the intravascular passage of the dye and its diffusion into the foveal tissue. The indocyanine green curve represents only the intravascular passage of indocyanine green dye. The difference between the two curves provides information on the accumulation of fluorescein in the macula. The characteristics of the fluorescein and indocyanine green curves have been determined for subjects with various degrees of ocular pigmentation.
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ISSN:0014-4835
1096-0007
DOI:10.1016/0014-4835(77)90280-9