Effect of phenobarbital on theophylline disposition

The effect of chronic phenobarbital administration on the pharmacokinetics of theophylline was studied in 6 healthy, nonsmoking adults. Subject compliance was verified by the determination of plasma phenobarbital levels. Following four weeks of phenobarbital administration, all six subjects showed a...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 62; no. 1; pp. 27 - 29
Main Authors Landay, Ronald A., Gonzalez, Mario A., Taylor, John C.
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.01.1978
Subjects
Adult
Biotransformation - drug effects
Female
Humans
Male
Metabolic Clearance Rate - drug effects
Phenobarbital - blood
Phenobarbital - pharmacology
Theophylline - blood
Theophylline - metabolism
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ISSN0091-6749
DOI10.1016/0091-6749(78)90068-4

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Summary:The effect of chronic phenobarbital administration on the pharmacokinetics of theophylline was studied in 6 healthy, nonsmoking adults. Subject compliance was verified by the determination of plasma phenobarbital levels. Following four weeks of phenobarbital administration, all six subjects showed a resultant increase in serum clearance varying from 11% to 60% with a mean increase of 34% (from 3.01 to 4.04 L/hr/1.73 M 2 ). Theophylline appears to be metabolized more rapidly during chronic phenobarbital administration. This effect, therefore, must be taken into account when administering barbiturates to asthmatic patients for whom theophylline therapy is prescribed.
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ISSN:0091-6749
DOI:10.1016/0091-6749(78)90068-4