Automatic identification of atypical clinical fMRI results

• Published in: Neuroradiology Vol. 62; no. 12; pp. 1677 - 1688
• Main Authors: Jansma, J. Martijn, Rutten, Geert-Jan, Ramsey, Lenny E., Snijders, T. J., Bizzi, Alberto, Rosengarth, Katharina, Dodoo-Schittko, Frank, Hattingen, Elke, de la Peña, Mar Jiménez, von Campe, Gord, Jehna, Margit, Ramsey, Nick F.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2020; Springer Nature B.V
• Subjects: Abnormalities; Evaluation; Feasibility studies; Functional magnetic resonance imaging; Functional Neuroradiology; Glioma; Imaging; Medicine; Medicine & Public Health; Motor task performance; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Patients; Radiology; Template matching; Tumors; Functional MRI; Clinical fMRI; Language; Brain function; Motor cortex
• ISSN: 0028-3940; 1432-1920; 1432-1920
• DOI: 10.1007/s00234-020-02510-z

Purpose Functional MRI is not routinely used for neurosurgical planning despite potential important advantages, due to difficulty of determining quality. We introduce a novel method for objective evaluation of fMRI scan quality, based on activation maps. A template matching analysis (TMA) is presented and tested on data from two clinical fMRI protocols, performed by healthy controls in seven clinical centers. Preliminary clinical utility is tested with data from low-grade glioma patients. Methods Data were collected from 42 healthy subjects from seven centers, with standardized finger tapping (FT) and verb generation (VG) tasks. Copies of these “typical” data were deliberately analyzed incorrectly to assess feasibility of identifying them as “atypical.” Analyses of the VG task administered to 32 tumor patients assessed sensitivity of the TMA method to anatomical abnormalities. Results TMA identified all atypical activity maps for both tasks, at the cost of incorrectly classifying 3.6 (VG)–6.5% (FT) of typical maps as atypical. For patients, the average TMA was significantly higher than atypical healthy scans, despite localized anatomical abnormalities caused by a tumor. Conclusion This study supports feasibility of TMA for objective identification of atypical activation patterns for motor and verb generation fMRI protocols. TMA can facilitate the use and evaluation of clinical fMRI in hospital settings that have limited access to fMRI experts. In a clinical setting, this method could be applied to automatically flag fMRI scans showing atypical activation patterns for further investigation to determine whether atypicality is caused by poor scan data quality or abnormal functional topography.