Reference parameters for left ventricular wall thickness, thickening, and motion in stress myocardial perfusion CT: Global and regional assessment

• Published in: Clinical imaging Vol. 56; pp. 81 - 87
• Main Authors: Cho, Young Hoon, Kang, Joon-Won, Choi, Seong Hoon, Yang, Dong Hyun, Anh, Tran Thi Xuan, Shin, Eun-Seok, Kim, Young-Hak
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019; Elsevier Limited
• Subjects: Adenosine; Age; Automation; Blood pressure; Body mass index; Body size; Cardiac CT; Cardiac function; Cardiovascular disease; Computed tomography; Coronary artery; Coronary artery disease; Coronary vessels; Defects; Demographics; Diabetes; Electrocardiography; Gender; Heart; Heart diseases; Hypertension; Left ventricular function; Medical imaging; Myocardium; NMR; Nuclear magnetic resonance; Pain; Parameters; Perfusion; Population; Reference parameter; Regional analysis; Statistical analysis; Thickening; Tomography; Ventricle; Ventricular wall thickness; Wall motion abnormality; Wall thickness; Work stations; Germany; Cardiac CT; Wall motion abnormality; Reference parameter; Ventricular wall thickness; Left ventricular function
• ISSN: 0899-7071; 1873-4499; 1873-4499
• DOI: 10.1016/j.clinimag.2019.04.002

To use adenosine-induced stress CT myocardial perfusion imaging (CT-MPI) to determine normal reference values for left ventricle (LV) wall thickness (WT) and motion parameters. This study included 106 Korean subjects (52 men and 54 women) who underwent CT-MPI due to chest pain, but were not found to have any detectable mild or severe coronary artery disease or myocardial perfusion defect. The following quantitative parameters were assessed on the CT-MPI according to a 17-segment model: LV myocardial thickness at end-systolic (WTES) and end-diastolic (WTED) phases, systolic wall thickening (SWT), and wall motion (WM). The associations of the measured parameters with the subjects' demographic characteristics and comorbidities were also analyzed. Septal wall (7.2 mm) and basal-level (7.7 mm) LV myocardium demonstrated significantly higher WT (p < 0.001). SWT was highest in lateral (77.8%, p < 0.014) and apical (78.9%, p = 0.009) myocardium, while lateral (7.7 mm) and basal (6.7 mm) myocardium exhibited the greatest WM (p < 0.001). WT was significantly higher in men and younger (<60 years) subjects (all, p < 0.001). Hypertensive individuals presented with significantly higher SWT (79.9%, p = 0.024). LV WT exhibited statistically significant correlations (all positive, except for age) with age, height, weight, body surface area, body mass index, and systolic blood pressure (all, p < 0.010). The present study provides CT-MPI reference values for LV myocardial WT, SWT, and WM measured on an adult Korean population. Knowledge of such normal reference measurements would be beneficial for the efficient interpretation of CT-MPI examinations in populations of Asian ethnicity. •Reference values for the LV WT and other wall motion parameters obtained on CT-MPI are presented in this article•WT was higher in septal wall and basal-level, and significantly associated with age, height, weight, BMI, and blood pressure•SWT was highest in lateral and apical myocardium, while lateral and basal myocardium exhibited the greatest WM•Knowledge of such normal reference measurements could provide additional beneficial information during CT-MPI interpretations