Increased serum levels of TNF-α and decreased serum levels of IL-27 in patients with Parkinson disease and their correlation with disease severity

• Published in: Clinical neurology and neurosurgery Vol. 166; pp. 76 - 79
• Main Authors: Kouchaki, Ebrahim, Kakhaki, Reza Daneshvar, Tamtaji, Omid Reza, Dadgostar, Ehsan, Behnam, Mohammad, Nikoueinejad, Hassan, Akbari, Hossein
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2018; Elsevier Limited
• Subjects: Aged; Biomarkers - blood; Case-Control Studies; Cytokines; Female; Growth factors; H and Y; Hepatitis; Humans; IL-27; Inflammatory diseases; Interleukin 27; Interleukins - blood; Lupus; Male; Middle Aged; Movement disorders; Multiple sclerosis; Neurodegenerative diseases; Neurology; Parkinson disease; Parkinson Disease - blood; Parkinson Disease - diagnosis; Parkinson's disease; Pathogenesis; Phosphorylation; Psoriasis; Serum levels; Severity of Illness Index; Studies; TNF-α; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Iran; IL-27; Parkinson disease; TNF-α; H and Y
• ISSN: 0303-8467; 1872-6968; 1872-6968
• DOI: 10.1016/j.clineuro.2018.01.022

•This study has evaluated the correlation of serum levels of TNFα and IL-27 with Parkinson Disease severity (PD).•Serum levels of TNF-α increase and IL-27 reduce in patients with PD.•There was close correlation between disease severities of PD with changes in serum levels of TNF-α and IL-27. : Immunological basis of neurodegenerative diseases including Alzheimer and Parkinson disease (PD) has some important roles in their pathogenesis. There are conflicting studies to serum level of TNF-α in PD. Also, according to our finding there is no report evaluating serum level of IL-27 in PD. This study correlates the serum level of those factors with severity of PD. : In this case-control study, 83 patients with PD and 83 healthy volunteers were enrolled. The diagnosis was fulfilled in accordance with clinical diagnostic criteria of the UK Parkinson's Disease Society Brain Bank by two neurologists. The modified Hoehn and Yahr (H and Y) scale was used to evaluate the severity of PD. Serum levels of TNF-α and IL-27 were measured by Elisa. Correlation of H and Y scale with serum levels of these cytokines was evaluated. : The serum levels of TNF-α were increased and serum levels of IL-27 were decreased in patients with PD compared to those in healthy subjects (P < 0.0001). There was a significant correlation between serum levels of TNF-α and IL-27 with H and Y scale. : Our study showed that the serum levels of TNF-α and IL-27 may be important prognostic biomarkers of PD.