Factors influencing health-related quality of life in chronic liver disease

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 48; pp. 7786 - 7791
• Main Author: Sobhonslidsuk, Abhasnee
• Format: Journal Article
• Language: English
• Published: United States Department of Medicine, Faculty of Medicine,Ramathibodi Hospital, Mahidol University, Bangkok, Thailand%Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand%Faculty of Commerce and Accountancy,Thammasat University, Bangkok, Thailand 28.12.2006; Baishideng Publishing Group Co., Limited
• Subjects: Adolescent; Adult; Age Factors; Aged; Chronic Disease; Clinical Research; Cross-Sectional Studies; Female; Health Status; Humans; Liver Diseases - etiology; Liver Diseases - physiopathology; Liver Diseases - psychology; Male; Middle Aged; Quality of Life - psychology; Regression Analysis; Severity of Illness Index; Sex Factors; Socioeconomic Factors; Surveys and Questionnaires; Thailand; 慢性肝疾病; 生活质量; 病理机制; Thailand; Health-related quality of life; Cirrhosis; Chronic liver disease questionnaire; Chronic hepatitis; Short-form 36
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i48.7786

AIM： To investigate the factors contributing to healthrelated quality of life （HRQL） in chronic liver disease （CLD）. METHODS： Patients with CLD and age- and sexmatched normal subjects performed the validated Thai versions of the short-form 36 （SF-36） by health survey and chronic liver disease questionnaire （CLDQ）. Stepwise multiple regression analysis was used to assess the impact of disease severity, demography, causes of CLD, socioeconomic factors, and self-rating health perception on HRQL. RESULTS： Two-hundred and fifty patients with CLD and fifty normal subjects were enrolled into the study. Mean age and the numbers of low educated, unemployed, blue-collar career and poor health perception increased significantly from chronic hepatitis to Child＇s Classes A to B to C. Advanced stage of CLD was related to deterioration of HRQL. Increasing age and female reduced physical health area. Low socioeconomic factors and financial burden affected multiple areas of HRQL. In overall, the positive impact of self-rating health perception on HRQL was consistently showed. CONCLUSION： Advanced disease, old age, female sex, stages of chronic liver low socioeconomic status and financial burden are important factors reducing HRQL. Good health perception improves HRQL regardless of stages of liver disease.