Constant optimization of oral drug absorption kinetics in the compartment absorption and transit models using particle swarm optimization algorithm

• Published in: IOP conference series. Earth and environmental science Vol. 31; no. 1; pp. 12007 - 12012
• Main Authors: Prabowo, K, Sumaryada, T, Kartono, A
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.01.2016
• Subjects: Absorption; Algorithms; Atenolol; Computer simulation; Constants; Dependent variables; Drugs; Mathematical models; Optimization; Oral administration; Particle swarm optimization; Plasma; Prediction models; Swarm intelligence; Transit
• ISSN: 1755-1307; 1755-1315; 1755-1315
• DOI: 10.1088/1755-1315/31/1/012007

Simulation of predictive modeling oral drug namely Compartment Absorption and Transit (CAT) using Particle Swarm Optimization (PSO) algorithm has been performed. This research will be carried out optimization of kinetic constant value oral drug use PSO algorithm to obtain the best global transport constant values for CAT equation that can predict drug concentration in plasma. The value of drug absorption rate constant for drug atenolol 25 mg is k10, k12, k21, k13 and k31 with each value is 0.8562, 0.3736, 0.2191, 0.4334 and 1.000 have been obtained thus raising the value of the coefficient of determination of a model CAT. From the experimental data plasma drug concentrations used are Atenolol, the coefficient of determination (R2) obtained from simulations atenolol 25 mg (PSO) was 81.72% and 99.46%. Better correlation between the dependent variable as the drug concentration and explanatory variables such as mass medication, plasma volume, and rate of absorption of the drug has increased in CAT models using PSO algorithm. Based on the results of CAT models fit charts can predict drug concentration in plasma.