Gardnerella and vaginal health: the truth is out there

• Published in: FEMS microbiology reviews Vol. 44; no. 1; pp. 73 - 105
• Main Authors: Rosca, Aliona S, Castro, Joana, Sousa, Lúcia G V, Cerca, Nuno
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2020
• Subjects: Anaerobic bacteria; Antimicrobial agents; Bacteria; Biofilms; Disease transmission; Etiology; Homeostasis; Infection; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Niches; Sexually transmitted diseases; STD; Vagina; Vaginosis; microbial interactions; vaginal biofilms; antimicrobial tolerance; bacterial vaginosis; Gardnerella spp; STIs
• ISSN: 0168-6445; 1574-6976; 1574-6976
• DOI: 10.1093/femsre/fuz027

The human vagina is a dynamic ecosystem in which homeostasis depends on mutually beneficial interactions between the host and their microorganisms. However, the vaginal ecosystem can be thrown off balance by a wide variety of factors. Bacterial vaginosis (BV) is the most common vaginal infection in women of childbearing age but its etiology is not yet fully understood, with different controversial theories being raised over the years. What is generally accepted is that BV is often characterized by a shift in the composition of the normal vaginal microbiota, from a Lactobacillus species dominated microbiota to a mixture of anaerobic and facultative anaerobic bacteria. During BV, a polymicrobial biofilm develops in the vaginal microenvironment, being mainly composed of Gardnerella species. The interactions between vaginal microorganisms are thought to play a pivotal role in the shift from health to disease and might also increase the risk of sexually transmitted infections acquisition. Here, we review the current knowledge regarding the specific interactions that occur in the vaginal niche and discuss mechanisms by which these interactions might be mediated. Furthermore, we discuss the importance of novel strategies to fight chronic vaginal infections.