Age‐related alterations in human cortical microstructure across the lifespan: Insights from high‐gradient diffusion MRI

• Published in: Aging cell Vol. 23; no. 11; pp. e14267 - n/a
• Main Authors: Lee, Hansol, Lee, Hong‐Hsi, Ma, Yixin, Eskandarian, Laleh, Gaudet, Kyla, Tian, Qiyuan, Krijnen, Eva A., Russo, Andrew W., Salat, David H., Klawiter, Eric C., Huang, Susie Y.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.11.2024; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Aging - physiology; Atrophy; Brain research; Cell body; Cerebral Cortex - diagnostic imaging; Cortex (frontal); Cortex (parietal); cortical microstructure; cortical volume; Cross-Sectional Studies; Demographics; Diffusion Magnetic Resonance Imaging - methods; diffusion MRI; Female; Females; Humans; Kurtosis; Life span; Longevity - physiology; Magnetic resonance imaging; Male; Middle age; Middle Aged; Multiple sclerosis; Neurodegeneration; Neuroimaging; Occipital lobe; Prefrontal cortex; SANDI; Signal to noise ratio; Substantia grisea; Temporal lobe; Tissues; Young Adult; Young adults; cortical volume; diffusion MRI; aging; cell body; SANDI; cortical microstructure
• ISSN: 1474-9718; 1474-9726; 1474-9726
• DOI: 10.1111/acel.14267

The human brain undergoes age‐related microstructural alterations across the lifespan. Soma and Neurite Density Imaging (SANDI), a novel biophysical model of diffusion MRI, provides estimates of cell body (soma) radius and density, and neurite density in gray matter. The goal of this cross‐sectional study was to assess the sensitivity of high‐gradient diffusion MRI toward age‐related alterations in cortical microstructure across the adult lifespan using SANDI. Seventy‐two cognitively unimpaired healthy subjects (ages 19–85 years; 40 females) were scanned on the 3T Connectome MRI scanner with a maximum gradient strength of 300mT/m using a multi‐shell diffusion MRI protocol incorporating 8 b‐values and diffusion time of 19 ms. Intra‐soma signal fraction obtained from SANDI model‐fitting to the data was strongly correlated with age in all major cortical lobes (r = −0.69 to −0.60, FDR‐p < 0.001). Intra‐soma signal fraction (r = 0.48–0.63, FDR‐p < 0.001) and soma radius (r = 0.28–0.40, FDR‐p < 0.04) were significantly correlated with cortical volume in the prefrontal cortex, frontal, parietal, and temporal lobes. The strength of the relationship between SANDI metrics and age was greater than or comparable to the relationship between cortical volume and age across the cortical regions, particularly in the occipital lobe and anterior cingulate gyrus. In contrast to the SANDI metrics, all associations between diffusion tensor imaging (DTI) and diffusion kurtosis imaging metrics and age were low to moderate. These results suggest that high‐gradient diffusion MRI may be more sensitive to underlying substrates of neurodegeneration in the aging brain than DTI and traditional macroscopic measures of neurodegeneration such as cortical volume and thickness. We demonstrated age‐related alterations in gray matter microstructure in the cortex across the healthy adult lifespan using advanced biophysical modeling of diffusion MRI data acquired on the high‐gradient 3T Connectome MRI scanner. Lower intra‐soma signal fraction was observed in older adults compared to young and middle‐aged adults throughout the major cortical lobes. The regional cortical atrophy was accompanied by significant reductions in both intra‐soma signal fraction and soma radius.