Coronary leukocyte activation in relation to progression of coronary artery disease

Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and...

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Published inFrontiers of medicine Vol. 10; no. 1; pp. 85 - 90
Main Authors de Vries, Marijke A., Alipour, Arash, Birnie, Erwin, Westzaan, Andrew, van Santen, Selvetta, der Zwan, Ellen van, Liem, Anho H., der Meulen, Noëlle van, Castro Cabezas, Manuel
Format Journal Article
LanguageEnglish
Published Beijing Higher Education Press 01.03.2016
Springer Nature B.V
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ISSN2095-0217
2095-0225
DOI10.1007/s11684-016-0435-1

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Summary:Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CDllb, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two- vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142-2358). During follow-up, 13 patients (13%) developed progression of CAD. Monoeyte CDllb, neutrophil CDllb and CD66b expression and intraceilular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CDllb, neutrophil CDllb and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.
Bibliography:Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CDllb, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two- vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142-2358). During follow-up, 13 patients (13%) developed progression of CAD. Monoeyte CDllb, neutrophil CDllb and CD66b expression and intraceilular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CDllb, neutrophil CDllb and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.
coronary artery disease; inflammation; integrin; myeloperoxidase; leukocyte activation
11-5983/R
coronary artery disease
leukocyte activation
inflammation
Document received on :2015-10-16
myeloperoxidase
Document accepted on :2016-01-06
integrin
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2095-0217
2095-0225
DOI:10.1007/s11684-016-0435-1