Belantamab Mafodotin: From Clinical Trials Data to Real-Life Experiences

• Published in: Cancers Vol. 15; no. 11; p. 2948
• Main Authors: Morè, Sonia, Offidani, Massimo, Corvatta, Laura, Petrucci, Maria Teresa, Fazio, Francesca
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.05.2023; MDPI
• Subjects: Antigens; Antimitotic agents; Antineoplastic agents; Apoptosis; B cells; Biological products; Blood diseases; CD38 antigen; Cell surface; Clinical trials; Cytotoxicity; Data collection; Drug approval; Drugs; FDA approval; Hematology; Immune system; Immunomodulation; Immunotherapy; Independent regulatory commissions; Investigations; Medical innovations; Medical research; Medicine, Experimental; Monoclonal antibodies; Multiple myeloma; Patients; Plasma; Product development; Proteasome inhibitors; Proteasomes; Proteins; Review; Toxicity; Transplants & implants; Tumor necrosis factor-TNF; belantamab mafodotin; multiple myeloma; antibody–drug conjugate
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers15112948

Despite the recent approval of novel immunotherapies, such as immunomodulatory drugs, proteasome inhibitors and anti-CD38 monoclonal antibodies, Multiple Myeloma (MM) remains incurable, and the acquisition of triple-refractoriness leads to really dismal outcomes in even earlier lines of therapy. More recently, innovative therapeutic strategies targeting B cell maturation antigen (BCMA), highly expressed on the plasma cell surface, are drawing different future landscapes in terms of effectiveness and outcomes. Belantamab Mafodotin, a first-in-class anti-BCMA antibody–drug conjugate, demonstrated good efficacy and safety profile in triple-refractory patients in the phase 2 DREAMM-2 trial, and it was approved for the treatment of MM triple-exposed patients with >4 prior lines of therapy. Here, starting from Belantamab Mafodotin clinical trials and also exploring combination studies and different schedules in order to improve its efficacy and toxicity, we focused on real-life experiences all over the world, which have confirmed clinical trial data and encourage further Belantamab Mafodotin investigations.