Animal model of intestinal anti-inflammatory effect of ginger-cinnamon complex
This study evaluated the anti-inflammatory effect of ginger-cinnamon mixture using an animal model of dextran sulfate sodium (DSS)-induced intestinal inflammation. The mice were administered either distilled water or ginger extract (GE), cinnamon subcritical water extract (CSWE), low GE + CSWE (GCL)...
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| Published in | Food science and biotechnology Vol. 30; no. 9; pp. 1249 - 1256 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Singapore
Springer Singapore
01.09.2021
Springer Nature B.V 한국식품과학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-7708 2092-6456 2092-6456 |
| DOI | 10.1007/s10068-021-00965-1 |
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| Abstract | This study evaluated the anti-inflammatory effect of ginger-cinnamon mixture using an animal model of dextran sulfate sodium (DSS)-induced intestinal inflammation. The mice were administered either distilled water or ginger extract (GE), cinnamon subcritical water extract (CSWE), low GE + CSWE (GCL), and high GE + CSWE (GCH) for 21 days and drinking water containing 5% DSS for the final 7 days to induce intestinal inflammation. We assessed the change of body weight, disease activity index (DAI), histopathological scores, myeloperoxidase (MPO) activity, and mRNA levels. Compared with the DSS group, the GCH group showed increased body weight, inhibited intestinal shortening, and decreased DAI and histopathological score of intestinal inflammation, which was similar to that for the control group. It inhibited MPO activity as well as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α mRNA levels. Therefore, the ginger–cinnamon complex helps to improve intestine inflammation, which is beneficial for gut health. |
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| AbstractList | This study evaluated the anti-inflammatory effect of ginger-cinnamon mixture using an animal model of dextran sulfate sodium (DSS)-induced intestinal inflammation. The mice were administered either distilled water or ginger extract (GE), cinnamon subcritical water extract (CSWE), low GE + CSWE (GCL), and high GE + CSWE (GCH) for 21 days and drinking water containing 5% DSS for the final 7 days to induce intestinal inflammation. We assessed the change of body weight, disease activity index (DAI), histopathological scores, myeloperoxidase (MPO) activity, and mRNA levels. Compared with the DSS group, the GCH group showed increased body weight, inhibited intestinal shortening, and decreased DAI and histopathological score of intestinal inflammation, which was similar to that for the control group. It inhibited MPO activity as well as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α mRNA levels. Therefore, the ginger-cinnamon complex helps to improve intestine inflammation, which is beneficial for gut health.This study evaluated the anti-inflammatory effect of ginger-cinnamon mixture using an animal model of dextran sulfate sodium (DSS)-induced intestinal inflammation. The mice were administered either distilled water or ginger extract (GE), cinnamon subcritical water extract (CSWE), low GE + CSWE (GCL), and high GE + CSWE (GCH) for 21 days and drinking water containing 5% DSS for the final 7 days to induce intestinal inflammation. We assessed the change of body weight, disease activity index (DAI), histopathological scores, myeloperoxidase (MPO) activity, and mRNA levels. Compared with the DSS group, the GCH group showed increased body weight, inhibited intestinal shortening, and decreased DAI and histopathological score of intestinal inflammation, which was similar to that for the control group. It inhibited MPO activity as well as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α mRNA levels. Therefore, the ginger-cinnamon complex helps to improve intestine inflammation, which is beneficial for gut health. This study evaluated the anti-inflammatory effect of ginger-cinnamon mixture using an animal model of dextran sulfate sodium (DSS)-induced intestinal inflammation. The mice were administered either distilled water or ginger extract (GE), cinnamon subcritical water extract (CSWE), low GE + CSWE (GCL), and high GE + CSWE (GCH) for 21 days and drinking water containing 5% DSS for the final 7 days to induce intestinal inflammation. We assessed the change of body weight, disease activity index (DAI), histopathological scores, myeloperoxidase (MPO) activity, and mRNA levels. Compared with the DSS group, the GCH group showed increased body weight, inhibited intestinal shortening, and decreased DAI and histopathological score of intestinal inflammation, which was similar to that for the control group. It inhibited MPO activity as well as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α mRNA levels. Therefore, the ginger–cinnamon complex helps to improve intestine inflammation, which is beneficial for gut health. This study evaluated the anti-inflammatoryeffect of ginger-cinnamon mixture using an animal modelof dextran sulfate sodium (DSS)-induced intestinalinflammation. The mice were administered either distilledwater or ginger extract (GE), cinnamon subcritical waterextract (CSWE), low GE ? CSWE (GCL), and highGE ? CSWE (GCH) for 21 days and drinking water containing5% DSS for the final 7 days to induce intestinalinflammation. We assessed the change of body weight,disease activity index (DAI), histopathological scores,myeloperoxidase (MPO) activity, and mRNA levels. Compared with the DSS group, the GCH group showedincreased body weight, inhibited intestinal shortening, anddecreased DAI and histopathological score of intestinalinflammation, which was similar to that for the controlgroup. It inhibited MPO activity as well as interleukin (IL)-1b, IL-6, and tumor necrosis factor-a mRNA levels. Therefore, the ginger–cinnamon complex helps to improveintestine inflammation, which is beneficial for gut health. KCI Citation Count: 2 This study evaluated the anti-inflammatory effect of ginger-cinnamon mixture using an animal model of dextran sulfate sodium (DSS)-induced intestinal inflammation. The mice were administered either distilled water or ginger extract (GE), cinnamon subcritical water extract (CSWE), low GE + CSWE (GCL), and high GE + CSWE (GCH) for 21 days and drinking water containing 5% DSS for the final 7 days to induce intestinal inflammation. We assessed the change of body weight, disease activity index (DAI), histopathological scores, myeloperoxidase (MPO) activity, and mRNA levels. Compared with the DSS group, the GCH group showed increased body weight, inhibited intestinal shortening, and decreased DAI and histopathological score of intestinal inflammation, which was similar to that for the control group. It inhibited MPO activity as well as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α mRNA levels. Therefore, the ginger–cinnamon complex helps to improve intestine inflammation, which is beneficial for gut health. |
| Author | shin, Jae-Ho Kim, Ji Yeon Im, Jin A Kim, Min Seo Kwon, Oran |
| Author_xml | – sequence: 1 givenname: Jin A surname: Im fullname: Im, Jin A organization: Department of Food Science and Technology, Seoul National University of Science and Technology – sequence: 2 givenname: Min Seo surname: Kim fullname: Kim, Min Seo organization: Department of Food Science and Technology, Seoul National University of Science and Technology – sequence: 3 givenname: Oran surname: Kwon fullname: Kwon, Oran organization: Department of Nutritional Science and Food Management, Ewha Womans University – sequence: 4 givenname: Jae-Ho surname: shin fullname: shin, Jae-Ho organization: Department of Biomedical Laboratory Science, Eulji University – sequence: 5 givenname: Ji Yeon orcidid: 0000-0002-4316-2726 surname: Kim fullname: Kim, Ji Yeon email: jiyeonk@seoultech.ac.kr organization: Department of Food Science and Technology, Seoul National University of Science and Technology |
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| Cites_doi | 10.5352/JLS.2016.26.9.1082 10.1016/j.biortech.2007.07.050 10.3748/wjg.v17.i8.976 10.1007/s10068-018-0438-6 10.1111/all.12122 10.1016/0378-8741(89)90085-8 10.2337/diacare.26.12.3215 10.1016/S0378-8741(98)00026-9 10.1007/s10068-019-00649-x 10.1186/1471-2407-10-392 10.3945/jn.108.100495 10.1080/07315724.2009.10719756 10.1097/01.MIB.0000195385.19268.68 10.4162/nrp.2015.9.1.3 10.3839/jabc.2017.050 10.7759/cureus.1004 10.1054/plef.2002.0441 10.1007/s10068-019-00616-6 10.1016/0167-5699(96)80606-2 10.1016/j.jnutbio.2015.11.015 10.1007/s003840050178 10.1046/j.1365-2249.1998.00728.x 10.2337/dc07-1711 10.1089/jmf.2005.8.149 10.1136/gut.2004.043372 10.1186/1471-2407-10-210 10.1590/S0365-05962012000500001 10.1089/jmf.2005.8.125 |
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| References | Cha J, Kim C-T, Kim T-E, Cho Y-J. Optimization of subcritical extraction process for cinnamon (Cinnamomum Cassia Blume) using response surface methodology. Food Science and Biotechnology. 28(6): 1703-1711 (2019) Kanuri G, Weber S, Volynets V, Spruss A, Bischoff SC, Bergheim I. Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. The Journal of Nutrition. 139: 482-487 (2009) Shen C-L, Hong K-J, Kim SW. Comparative effects of ginger root (Zingiber officinale Rosc.) on the production of inflammatory mediators in normal and osteoarthrotic sow chondrocytes. Journal of Medicinal Food. 8(2): 149-153 (2005) Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunology Today. 17(3): 138-146 (1996) Kim CY. Inhibition of interleukin-1α-induced intestinal epithelial tight junction permeability by curcumin treatment in Caco-2 Cells in Caco-2 cells. Journal of Life Science. 26(9): 1082-1087 (2016) Kwon H-K, Hwang J-S, So J-S, Lee C-G, Sahoo A, Ryu J-H, Jeon WK, Ko BS, Im C-R, Lee S-H, Park ZY, Im S-H. Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1. BMC Cancer. 10(1): 1-10 (2010) Schottelius A, Baldwin Jr A. A role for transcription factor NF-kB in intestinal inflammation. International Journal of Colorectal Disease. 14(1): 18-28 (1999) Kwon H-K, Hwang J-S, Lee C-G, So JS, Sahoo A, Im C-R, Jeon WK, Ko BS, Lee SH, Park ZY, Im SH. Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells. World Journal of Gastroenterology: WJG. 17: 976 (2011) Kim MJ, Kim MS, Kang ST, Kim JY. Effect of ginger and cinnamon extract mixtures on the growth of intestinal bacteria and intestinal inflammation. Journal of Applied Biological Chemistry. 60: 321-326 (2017) Khan A, Safdar M, Khan MMA, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 26: 3215-3218 (2003) Kim J, Kim D. Nutritional composition containing ginger extract for enhancing tight junctions in intestinal cells and prepeparing method thereof. Korea Patent 10-2016 (2016) Cooper HS, Murthy S, Shah R, Sedergran D. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Laboratory Investigation; A Journal of Technical Methods and Pathology. 69: 238-249 (1993) Hagenlocher Y, Hösel A, Bischoff SC, Lorentz A. Cinnamon extract reduces symptoms, inflammatory mediators and mast cell markers in murine IL-10−/− colitis. The Journal of Nutritional Biochemistry. 30: 85-92 (2016) Thomson M, Al-Qattan K, Al-Sawan S, Alnaqeeb M, Khan I, Ali M. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins, Leukotrienes and Essential Fatty Acids. 67: 475-478 (2002) Grzanna R, Lindmark L, Frondoza CG. Ginger—an herbal medicinal product with broad anti-inflammatory actions. Journal of Medicinal Food. 8(2): 125-132 (2005) Roussel A-M, Hininger I, Benaraba R, Ziegenfuss TN, Anderson RA. Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. Journal of the American College of Nutrition. 28(1): 16-21 (2009) Rees V. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clinical & Experimental Immunology. 114: 385-391 (1998) Baker WL, Gutierrez-Williams G, White CM, Kluger J, Coleman CI. Effect of cinnamon on glucose control and lipid parameters. Diabetes Care. 31: 41-43 (2008) Carter MJ, Lobo AJ, Travis SP. Guidelines for the management of inflammatory bowel disease in adults. Gut. 53: v1-v16 (2004) Kim MS, Kim JY. Ginger attenuates inflammation in a mouse model of dextran sulfate sodium-induced colitis. Food Science and Biotechnology. 27(5): 1493-1501 (2018) Kim K-M, Kim Y-S, Lim JY, Min SJ, Ko H-C, Kim S-J, Kim Y. Intestinal anti-inflammatory activity of Sasa quelpaertensis leaf extract by suppressing lipopolysaccharide-stimulated inflammatory mediators in intestinal epithelial Caco-2 cells co-cultured with RAW 264.7 macrophage cells. Nutrition Research and Practice. 9: 3 (2015) Bhandari U, Sharma J, Zafar R. The protective action of ethanolic ginger (Zingiber officinale) extract in cholesterol fed rabbits. Journal of Ethnopharmacology. 61(2): 167-171 (1998) Brotas AM, Cunha JMT, Lago EHJ, Machado CCN, Carneiro SCdS. Tumor necrosis factor-alpha and the cytokine network in psoriasis. Anais brasileiros de dermatologia. 87: 673-683 (2012) Hansberry DR, Shah K, Agarwal P, Agarwal N. Fecal myeloperoxidase as a biomarker for inflammatory bowel disease. Cureus. 9(1): e1004 (2017) Mascolo N, Jain R, Jain S, Capasso F. Ethnopharmacologic investigation of ginger (Zingiber officinale). Journal of Ethnopharmacology. 27(1-2): 129-140 (1989) Tung Y-T, Chua M-T, Wang S-Y, Chang S-T. Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresource Technology. 99: 3908-3913 (2008) Park S-H, Jung S-J, Choi E-K, Ha K-C, Baek H-I, Park Y-K, Han K-H, Jeong S-Y, Oh J-H, Cha Y-S, Park B-H, Chae S-W. The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial. Food Science and Biotechnology. 29: 265-273 (2020) Hanauer SB. Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflammatory Bowel Diseases. 12: S3-S9 (2006) Koppikar SJ, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R. Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer. 10(1): 1-12 (2010) Hagenlocher Y, Bergheim I, Zacheja S, Schäffer M, Bischoff S, Lorentz A. Cinnamon extract inhibits degranulation and de novo synthesis of inflammatory mediators in mast cells. Allergy. 68: 490-497 (2013) 965_CR19 965_CR17 965_CR18 965_CR15 965_CR16 965_CR13 965_CR14 965_CR11 965_CR12 965_CR10 965_CR30 965_CR9 965_CR8 965_CR7 965_CR6 965_CR5 965_CR4 965_CR3 965_CR28 965_CR2 965_CR29 965_CR1 965_CR26 965_CR27 965_CR24 965_CR25 965_CR22 965_CR23 965_CR20 965_CR21 |
| References_xml | – reference: Cooper HS, Murthy S, Shah R, Sedergran D. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Laboratory Investigation; A Journal of Technical Methods and Pathology. 69: 238-249 (1993) – reference: Kanuri G, Weber S, Volynets V, Spruss A, Bischoff SC, Bergheim I. Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. The Journal of Nutrition. 139: 482-487 (2009) – reference: Hanauer SB. Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflammatory Bowel Diseases. 12: S3-S9 (2006) – reference: Cha J, Kim C-T, Kim T-E, Cho Y-J. Optimization of subcritical extraction process for cinnamon (Cinnamomum Cassia Blume) using response surface methodology. Food Science and Biotechnology. 28(6): 1703-1711 (2019) – reference: Kim K-M, Kim Y-S, Lim JY, Min SJ, Ko H-C, Kim S-J, Kim Y. Intestinal anti-inflammatory activity of Sasa quelpaertensis leaf extract by suppressing lipopolysaccharide-stimulated inflammatory mediators in intestinal epithelial Caco-2 cells co-cultured with RAW 264.7 macrophage cells. Nutrition Research and Practice. 9: 3 (2015) – reference: Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunology Today. 17(3): 138-146 (1996) – reference: Schottelius A, Baldwin Jr A. A role for transcription factor NF-kB in intestinal inflammation. International Journal of Colorectal Disease. 14(1): 18-28 (1999) – reference: Thomson M, Al-Qattan K, Al-Sawan S, Alnaqeeb M, Khan I, Ali M. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins, Leukotrienes and Essential Fatty Acids. 67: 475-478 (2002) – reference: Park S-H, Jung S-J, Choi E-K, Ha K-C, Baek H-I, Park Y-K, Han K-H, Jeong S-Y, Oh J-H, Cha Y-S, Park B-H, Chae S-W. The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial. Food Science and Biotechnology. 29: 265-273 (2020) – reference: Kwon H-K, Hwang J-S, Lee C-G, So JS, Sahoo A, Im C-R, Jeon WK, Ko BS, Lee SH, Park ZY, Im SH. Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells. World Journal of Gastroenterology: WJG. 17: 976 (2011) – reference: Kim MS, Kim JY. Ginger attenuates inflammation in a mouse model of dextran sulfate sodium-induced colitis. Food Science and Biotechnology. 27(5): 1493-1501 (2018) – reference: Koppikar SJ, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R. Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer. 10(1): 1-12 (2010) – reference: Brotas AM, Cunha JMT, Lago EHJ, Machado CCN, Carneiro SCdS. Tumor necrosis factor-alpha and the cytokine network in psoriasis. Anais brasileiros de dermatologia. 87: 673-683 (2012) – reference: Khan A, Safdar M, Khan MMA, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 26: 3215-3218 (2003) – reference: Shen C-L, Hong K-J, Kim SW. Comparative effects of ginger root (Zingiber officinale Rosc.) on the production of inflammatory mediators in normal and osteoarthrotic sow chondrocytes. Journal of Medicinal Food. 8(2): 149-153 (2005) – reference: Bhandari U, Sharma J, Zafar R. The protective action of ethanolic ginger (Zingiber officinale) extract in cholesterol fed rabbits. Journal of Ethnopharmacology. 61(2): 167-171 (1998) – reference: Kim MJ, Kim MS, Kang ST, Kim JY. Effect of ginger and cinnamon extract mixtures on the growth of intestinal bacteria and intestinal inflammation. 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| SubjectTerms | Animal models anti-inflammatory activity biotechnology Body weight Chemistry Chemistry and Materials Science cinnamon Dextran Dextran sulfate Dextrans Distilled water Drinking water Food Science Ginger histopathology Inflammation Interleukin 6 Intestine intestines mRNA myeloperoxidase necrosis neoplasms Nutrition Peroxidase Research Article Tumor necrosis factor-α 식품과학 |
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| Title | Animal model of intestinal anti-inflammatory effect of ginger-cinnamon complex |
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