Animal model of intestinal anti-inflammatory effect of ginger-cinnamon complex

• Published in: Food science and biotechnology Vol. 30; no. 9; pp. 1249 - 1256
• Main Authors: Im, Jin A, Kim, Min Seo, Kwon, Oran, shin, Jae-Ho, Kim, Ji Yeon
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.09.2021; Springer Nature B.V; 한국식품과학회
• Subjects: Animal models; anti-inflammatory activity; biotechnology; Body weight; Chemistry; Chemistry and Materials Science; cinnamon; Dextran; Dextran sulfate; Dextrans; Distilled water; Drinking water; Food Science; Ginger; histopathology; Inflammation; Interleukin 6; Intestine; intestines; mRNA; myeloperoxidase; necrosis; neoplasms; Nutrition; Peroxidase; Research Article; Tumor necrosis factor-α; 식품과학; Ginger; Extract mixtures; Cinnamon; Intestine; Anti-inflammatory
• ISSN: 1226-7708; 2092-6456; 2092-6456
• DOI: 10.1007/s10068-021-00965-1

This study evaluated the anti-inflammatory effect of ginger-cinnamon mixture using an animal model of dextran sulfate sodium (DSS)-induced intestinal inflammation. The mice were administered either distilled water or ginger extract (GE), cinnamon subcritical water extract (CSWE), low GE + CSWE (GCL), and high GE + CSWE (GCH) for 21 days and drinking water containing 5% DSS for the final 7 days to induce intestinal inflammation. We assessed the change of body weight, disease activity index (DAI), histopathological scores, myeloperoxidase (MPO) activity, and mRNA levels. Compared with the DSS group, the GCH group showed increased body weight, inhibited intestinal shortening, and decreased DAI and histopathological score of intestinal inflammation, which was similar to that for the control group. It inhibited MPO activity as well as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α mRNA levels. Therefore, the ginger–cinnamon complex helps to improve intestine inflammation, which is beneficial for gut health.