Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson’s Disease in Asian Population: A Meta-Analysis

• Published in: Genes Vol. 12; no. 5; p. 674
• Main Authors: Chiang, Han-Lin, Wu, Yih-Ru, Chen, Yi-Chun, Fung, Hon-Chung, Chen, Chiung-Mei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.04.2021; MDPI
• Subjects: 3' Untranslated regions; Alleles; Axons; China; Enzymes; Fibroblast growth factor 20; fibroblast growth factors; Fibroblasts; Gene polymorphism; genotype; Genotype & phenotype; Growth factors; Lewy bodies; Meta-analysis; Movement disorders; neurites; Neurodegenerative diseases; Parkinson's disease; Polymorphism; Population; Population genetics; protective effect; risk; Single-nucleotide polymorphism; Software; Statistical analysis; Synuclein; United States > US; China; FGF20; fibroblast growth factor 20; rs591323; Parkinson’s disease
• ISSN: 2073-4425; 2073-4425
• DOI: 10.3390/genes12050674

Parkinson’s disease (PD) is a neurodegenerative disease with the pathological hallmark of Lewy bodies and Lewy neurites composed of α-synuclein. The SNP rs591323 is one of the risk loci located near the FGF20 gene that has been implicated in PD. The variation of FGF20 in the 3′ untranslated region was shown to increase α-synuclein expression. We examined the association of rs591323 with the risk of PD in a Taiwanese population and conducted a meta-analysis, including our study and two other studies from China, to further confirm the role of this SNP in Taiwanese/Chinese populations. A total of 586 patients with PD and 586 health controls (HCs) were included in our study. We found that the minor allele (A) and the AA + GA genotype under the dominant model are significantly less frequent in PD than in controls. The meta-analysis consisted of 1950 patients with PD and 2073 healthy controls from three studies. There was significant association between rs591323 and the risk of PD in the additive (Z = −3.96; p < 0.0001) and the dominant models (Z = −4.01; p < 0.0001). Our study results and the meta-analysis support the possible protective role of the rs591323 A allele in PD in Taiwanese/Chinese populations.