Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials

• Published in: Journal of cardiovascular development and disease Vol. 10; no. 12; p. 499
• Main Authors: Lim, Gareth Zigui, Lai, Jonathan Yexian, Seet, Christopher Ying Hao, Tham, Carol Huilian, Venketasubramanian, Narayanaswamy, Tan, Benjamin Yong Qiang, Jing, Mingxue, Yeo, Joshua Yee Peng, Myint, May Zin, Sia, Ching-Hui, Teoh, Hock Luen, Sharma, Vijay Kumar, Chan, Bernard Poon Lap, Yang, Cunli, Makmur, Andrew, Ong, Shao Jin, Yeo, Leonard Leong Litt
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2023
• Subjects: acute; Clinical trials; Edema; endovascular treatment; ischaemic stroke; Ischemia; Meta-analysis; MRI; radiology; Resveratrol; Software; Stroke; Stroke (Disease); Japan; Singapore; CT; acute; ischaemic stroke; large infarcts; MRI; radiology; endovascular treatment
• ISSN: 2308-3425; 2308-3425
• DOI: 10.3390/jcdd10120499

Endovascular therapy (EVT) has revolutionized the management of acute ischaemic strokes with large vessel occlusion, with emerging evidence suggesting its benefit also in large infarct core volume strokes. In the last two years, four randomised controlled trials have been published on this topic—RESCUE-Japan LIMIT, ANGEL-ASPECT, SELECT2 and TENSION, with overall results showing that EVT improves functional and neurological outcomes compared to medical management alone. This review aims to summarise the recent evidence presented by these four trials and highlight some of the limitations in our current understanding of this topic.