Adrenal hormones before and after venography during adrenal venous sampling: a self-controlled study

• Published in: Japanese journal of radiology Vol. 35; no. 3; pp. 126 - 130
• Main Authors: Koike, Yuya, Matsui, Seishi, Omura, Masao, Makita, Kohzoh, Obara, Alfonso W. D., Moriya, Nobukazu, Nishikawa, Tetsuo
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.03.2017; Springer Nature B.V
• Subjects: Adrenal Glands - blood supply; Aldosterone - blood; Blood Specimen Collection - methods; Catheterization, Peripheral - methods; Contrast Media - administration & dosage; Female; Humans; Hydrocortisone - blood; Hyperaldosteronism - blood; Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Nuclear Medicine; Original Article; Prospective Studies; Radiology; Radiotherapy; Stress, Physiological - physiology; Veins - diagnostic imaging; Primary aldosteronism; Adrenal vein sampling; Contrast materials
• ISSN: 1867-1071; 1867-108X; 1867-108X
• DOI: 10.1007/s11604-017-0612-4

Objective A stress reaction involving increased adrenal hormone release occurs when starting adrenal venous sampling (AVS). The purpose of the present study was to investigate the effect of single shot venography on adrenal hormone production during AVS. Subjects and methods This was a prospective self-controlled study. We enrolled 54 consecutive patients (21 men, 33 women; mean age 52 ± 11 years) with primary aldosteronism who underwent AVS from May 2014 to February 2015. Under non-stimulated conditions, blood samples were obtained from a common trunk of the left adrenal vein before and after single shot venography. The initial plasma aldosterone and cortisol concentration (PAC and PCC) were compared with those measured after venography for each patient. Results PAC and PCC were slightly but significantly decreased between before and after venography (after log transformation 2.12 ± 0.73 vs 2.07 ± 0.72, P  = 0.00066, 1.89 ± 0.52 vs 1.83 ± 0.53, P  = 0.00031, respectively). Conclusions During non-stimulated left AVS, adrenal hormone secretion was slightly but significantly decreased after venography, similar to the normal time-related stress reaction. Venography did not increase the adrenal hormone secretion.