Rectal carcinosarcoma： A case report and review of literature

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 9; pp. 1481 - 1484
• Main Author: Tsekouras, Dimitrios Konstantinos
• Format: Journal Article
• Language: English
• Published: United States 1st University De partment of General Surgery, Athens School of Medicine, Ippokration Hospital, Athens, Greece%Department of Pathology, Ippokration Hospital,Athens, Greece 07.03.2006; Baishideng Publishing Group Co., Limited
• Subjects: Biomarkers - analysis; Carcinosarcoma - chemistry; Carcinosarcoma - diagnosis; Carcinosarcoma - pathology; Carcinosarcoma - therapy; Case Report; Combined Modality Therapy; Humans; Immunohistochemistry; Keratins - analysis; Male; Middle Aged; Rectal Neoplasms - chemistry; Rectal Neoplasms - diagnosis; Rectal Neoplasms - pathology; Rectal Neoplasms - therapy; Tumor Suppressor Protein p53 - analysis; 治疗; 病理报告; 病理机制; 直肠癌; Carcinosarcoma; Rectum
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i9.1481

A 60-years old male was admitted to our department for investigation of constipation and hypogastric discomfort intensified during defecation of a few weeks duration. The cause proved to be a rectal carcinosarcoma that was treated by abdominoperineal resection and postoperative chemo-radiotherapy. The patient died 6 months later due to hepatic failure, showing evidence of disseminated disease. In general colonic carcinosarcomas constitute a rare category of malignant neoplasms whose nature is still incompletely understood. No specific treatment guidelines exist. Surgery is the mainstay of treatment and regardless of the addition of adjuvant therapy the prognosis is very poor. Systematic genetic analysis may be the clue for understanding the pathogenesis of these mysterious tumors.