Effect of Bronchoconstriction on Airway Remodeling in Asthma

Airway remodeling in asthma has been classically considered to be the result of inflammatory changes. In this study, the investigators show that bronchoconstriction alone can result in changes consistent with airway remodeling. Asthma is a common chronic respiratory condition characterized clinicall...

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Published inThe New England journal of medicine Vol. 364; no. 21; pp. 2006 - 2015
Main Authors Grainge, Christopher L, Lau, Laurie C.K, Ward, Jonathon A, Dulay, Valdeep, Lahiff, Gemma, Wilson, Susan, Holgate, Stephen, Davies, Donna E, Howarth, Peter H
Format Journal Article
LanguageEnglish
Published Waltham, MA Massachusetts Medical Society 26.05.2011
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ISSN0028-4793
1533-4406
1533-4406
DOI10.1056/NEJMoa1014350

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Summary:Airway remodeling in asthma has been classically considered to be the result of inflammatory changes. In this study, the investigators show that bronchoconstriction alone can result in changes consistent with airway remodeling. Asthma is a common chronic respiratory condition characterized clinically by an excessive tendency toward reversible airway narrowing. This may arise in response to everyday environmental exposure and is worsened both by intercurrent infection and, in sensitized persons, by allergen exposure. In pathological terms, asthma is characterized by airway inflammation and by structural changes in airway tissues, such as epithelial goblet-cell hyperplasia, subepithelial collagen deposition, and smooth-muscle hypertrophy — collectively referred to as airway remodeling. 1 – 3 Since an inhaled-allergen challenge in atopic asthma induces eosinophilic inflammation of the airway and changes in the extracellular matrix, 4 and since a reduction in airway . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1014350