Analysis of Risk Factors for High-Risk Lymph Node Metastasis in Papillary Thyroid Microcarcinoma

• Published in: Cancers Vol. 17; no. 15; p. 2585
• Main Authors: Chiu, Yi-Hsiang, Wu, Shu-Ting, Chen, Yung-Nien, Chen, Wen-Chieh, Lim, Lay-San, Chiew, Yvonne Ee Wern, Kuo, Ping-Chen, Yang, Ya-Chen, Chi, Shun-Yu, Chou, Chen-Kai
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.08.2025; MDPI
• Subjects: Age; Development and progression; Diseases; Lymph nodes; Lymphatic diseases; Lymphatic system; Males; Medical prognosis; Medical research; Medicine, Experimental; Metastases; Metastasis; Mutation; Patients; Relapse; Risk assessment; Risk factors; Sex; Survival; Thyroid cancer; Thyroidectomy; Taiwan; lymphatic metastasis; prognosis; thyroid neoplasms
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers17152585

Background: Papillary thyroid microcarcinoma (PTMC) is associated with certain features that carry an increased risk of local recurrence, underscoring the importance of preoperative risk assessment. This study investigated the clinicopathological factors associated with high-risk lymph node metastasis (HRLNM) and patient outcomes. HRLNM is defined as ≥5 metastatic lymph nodes and/or lateral neck metastasis. Methods: We conducted a retrospective review of 985 patients with PTMC who underwent thyroidectomy at the Kaohsiung Chang Gung Memorial Hospital from 2013 to 2022. Results: Among the 985 patients, 100 (10.2%) had lymph node metastasis (LNM), and 27% of these were classified as having HRLNM. Male sex (OR 3.61, p = 0.04) and extranodal extension (OR 3.76, p = 0.043) were independent predictors of HRLNM. Patients with LNM exhibited lower rates of excellent treatment response (75% vs. 87%, p = 0.001), higher recurrence rates (9.0% vs. 0.6%, p = 0.001), and an increased risk of distant metastasis (2.0% vs. 0%). Recurrence-free survival (RFS) was significantly shorter in patients with LNM (120.9 vs. 198.6 months, p < 0.001). Although HRLNM showed a trend toward reduced RFS (113.5 vs. 124.6 months, p = 0.177), its impact on long-term survival remains uncertain. Conclusions: Male sex and extranodal extension were significant risk factors for HRLNM in patients with PTMC. These findings highlight the need for individualized risk stratification to guide treatment strategies and improve patient outcomes.