Shear Induced Non-Linear Elasticity Imaging: Elastography for Compound Deformations

• Published in: IEEE transactions on medical imaging Vol. 39; no. 11; pp. 3559 - 3570
• Main Authors: Goswami, Soumya, Ahmed, Rifat, Khan, Siladitya, Doyley, Marvin M., McAleavey, Stephen A.
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.11.2020; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Acoustoelasticity; Axial compression; Axial strain; Bias; complex tissue motion; Compounds; Compression; Deformation; Elasticity; Elastography; Estimates; Linearity; material nonlinearity; Mechanical measurement; Mechanical properties; Mimicry; Noise levels; nonlinear elasticity; nonlinear shear modulus; Nonlinearity; Performance measurement; Production methods; Propagation; quasi-static and shear wave elastography; Shear deformation; Shear modulus; Shear strain; Signal to noise ratio; simple shearing; Strain; Tensors; Tissues; Ultrasound
• ISSN: 0278-0062; 1558-254X; 1558-254X
• DOI: 10.1109/TMI.2020.2999439

The goal of non-linear ultrasound elastography is to characterize tissue mechanical properties under finite deformations. Existing methods produce high contrast non-linear elastograms under conditions of pure uni-axial compression, but exhibit bias errors of 10-50% when the applied deformation deviates from the uni-axial condition. Since freehand transducer motion generally does not produce pure uniaxial compression, a motion-agnostic non-linearity estimator is desirable for clinical translation. Here we derive an expression for measurement of the Non-Linear Shear Modulus (NLSM) of tissue subject to combined shear and axial deformations. This method gives consistent nonlinear elasticity estimates irrespective of the type of applied deformation, with a reduced bias in NLSM values to 6-13%. The method combines quasi-static strain imaging with Single-Track Location-Shear Wave Elastography (STL-SWEI) to generate local estimates of axial strain, shear strain, and Shear Wave Speed (SWS). These local values were registered and non-linear elastograms reconstructed with a novel nonlinear shear modulus estimation scheme for general deformations. Results on tissue mimicking phantoms were validated with mechanical measurements and multiphysics simulations for all deformation types with an error in NLSM of 6-13%. Quantitative performance metrics with the new compound-motion tracking strategy reveal a 10-15 dB improvement in Signal-to-Noise Ratio (SNR) for simple shear versus pure compressive deformation for NLSM elastograms of homogeneous phantoms. Similarly, the Contrast-to-Noise Ratio (CNR) of NLSM elastograms of inclusion phantoms improved by 25-30% for simple shear over pure uni-axial compression. Our results show that high fidelity NLSM estimates may be obtained at ~30% lower strain under conditions of shear deformation as opposed axial compression. The reduction in strain required could reduce sonographer effort and improve scan safety.