Comparison of PPI and combined treatment in the treatment of recurrent laryngeal contact granuloma

• Published in: American journal of otolaryngology Vol. 42; no. 1; p. 102766
• Main Authors: Nie, Qian, Li, Jinrang, Zou, Shizhen, Zhang, Ran
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021; Elsevier Limited
• Subjects: Administration, Oral; Adult; Aerosols; Botulinum toxin; Calcification; Cartilage; Combined treatment; Drug Therapy, Combination; Female; Glucocorticoids; Glucocorticoids - administration & dosage; Granuloma; Granuloma, Laryngeal - drug therapy; Granulomas; Humans; Inflammation; Injections, Intralesional; Laryngeal contact granuloma; Larynx; Male; Middle Aged; Patients; PPI; Proton Pump Inhibitors - administration & dosage; Recurrence; Retrospective Studies; Statistical analysis; Subgroups; Surgery; Therapeutic effect; Trauma; Treatment; Treatment Outcome; PPI; Treatment; Therapeutic effect; Laryngeal contact granuloma
• ISSN: 0196-0709; 1532-818X; 1532-818X
• DOI: 10.1016/j.amjoto.2020.102766

To compare the therapeutic effect of PPI and combined treatment in the treatment of patients with recurrent laryngeal contact granuloma. The clinical data of 299 patients with recurrent laryngeal contact granuloma treated with PPI or combined treatment (PPI with glucocorticoid injection into granuloma by the thyroglossal approach) from February 2013 to June 2019 were analyzed retrospectively. Patients were divided into two subgroups: PPI and combined treatment. The cure rates, recurrence rates and cure time of the two subgroups were compared and analyzed separately. Than we can get the optimal treatment of the two treatment in the treatment of recurrent patients. In recurrent patients, the cure rate (81.20%) and recurrence rate (3%) of combined treatment were superior to those of PPI (57.58%) and recurrence rate (12.12%); (P < 0.05). The cure time of PPI was longer than that of combination therapy (P < 0.001). The therapeutic effect of combined treatment is better than that of PPI in patients with recurrence. At the same time, combined treatment is an effective treatment for recurrent granuloma and can be used as a first-line treatment for recurrent laryngeal contact granuloma.