Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design

• Published in: Brain and behavior Vol. 8; no. 12; pp. e01154 - n/a
• Main Authors: Han, Yongjun, Qiao, Huiyu, Chen, Shuo, Jing, Jing, Pan, Yuesong, Li, Dongye, Liu, Yang, Meng, Xia, Wang, Yilong, Zhao, Xihai
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2018; John Wiley and Sons Inc
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Atherosclerosis; Cerebrovascular Disorders - complications; Cerebrovascular Disorders - ethnology; Cerebrovascular Disorders - etiology; Cerebrovascular Disorders - pathology; China - ethnology; Constriction, Pathologic - ethnology; Constriction, Pathologic - etiology; Constriction, Pathologic - pathology; Disease Progression; Etiology; Female; Follow-Up Studies; Humans; Intracranial Arteriosclerosis - ethnology; Intracranial Arteriosclerosis - etiology; Intracranial Arteriosclerosis - pathology; intracranial artery; Ischemic Attack, Transient - ethnology; Ischemic Attack, Transient - etiology; Ischemic Attack, Transient - pathology; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Methods; Middle Aged; Plaque, Atherosclerotic - ethnology; Plaque, Atherosclerotic - etiology; Plaque, Atherosclerotic - pathology; progression; Prospective Studies; Risk Factors; stenosis; Stroke; Stroke - ethnology; Stroke - etiology; Stroke - pathology; Veins & arteries; Young Adult; China; Beijing China; atherosclerosis; progression; magnetic resonance imaging; intracranial artery; stenosis; etiology
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.1154

Background It has been shown that intracranial artery stenosis (ICAS) plays a key role in Chinese ischemic stroke or transient ischemic attack (TIA) patients. Many vascular diseases can lead to ICAS, such as atherosclerosis, dissection, vasculitis, moyamoya disease, and reversible cerebral vasoconstriction syndrome (RCVS). In addition, progression of intracranial atherosclerotic disease (ICAD) will increase the risk of ischemic cerebrovascular events. The ICASMAP study primarily aims to determine the etiology and disease distribution of ICAS using noninvasive magnetic resonance (MR) imaging and evaluate the rate for progression of ICAD in symptomatic population. Methods The ICASMAP study is a prospective, observational, and multicenter study by recruiting 300 subjects (18–80 years old) with recent stroke or TIA (within 2 weeks after onset of symptoms) in China. All the subjects will undergo MR imaging examination including brain and intracranial artery MR imaging at baseline. In addition, the clinical risk factors will be collected and blood biomarkers will be tested. A subgroup of more than 200 subjects who were diagnosed with ICAD according to baseline MR imaging will be followed up for 2 years. During the follow‐up study, MR imaging examination will be performed at 12 and 24 months. The primary end point is presence of progression of intracranial artery atherosclerotic plaques. Conclusions The ICASMAP study investigates the etiology of ICAS and progression of ICAD in Chinese stroke patients and may help to improve the precise diagnosis and intervention of ICAS and stroke prevention. The ICASMAP study aims to determine the etiology and disease distribution of ICAS using noninvasive magnetic resonance (MR) imaging and evaluate the risk factors for progression of ICAD in symptomatic population. In this study, we will recruit 300 subjects (18–80 years old) with recent stroke or TIA in China. The ICASMAP study investigates the etiology of ICAS and progression of ICAD in Chinese stroke patients and may help to improve the precise diagnosis and intervention of ICAS and stroke prevention.