Incomplete Systemic Lupus Erythematosus: What Remains After Application of American College of Rheumatology and Systemic Lupus International Collaborating Clinics criteria?

Incomplete systemic lupus (iSLE) is an acknowledged condition of patients with clinical signs of lupus who do not fulfill classification criteria for SLE. Some patients with iSLE have persistent mild disease, but others have serious organ involvement, and up to 55% progress to established SLE. Resea...

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Published inArthritis care & research (2010) Vol. 72; no. 5; pp. 607 - 614
Main Authors Lambers, Wietske M., Westra, Johanna, Jonkman, Marcel F., Bootsma, Hendrika, Leeuw, Karina
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.05.2020
John Wiley and Sons Inc
Subjects
Adult
Classification
Clinical trials
Decision Support Techniques
Disease Progression
Female
Humans
Lupus
Lupus Erythematosus, Systemic - classification
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - therapy
Male
Middle Aged
Patients
Predictive Value of Tests
Prognosis
Review
Risk Factors
Severity of Illness Index
Special
Systemic lupus erythematosus
Terminology as Topic
Online AccessGet full text
ISSN2151-464X
2151-4658
2151-4658
DOI10.1002/acr.23894

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Summary:Incomplete systemic lupus (iSLE) is an acknowledged condition of patients with clinical signs of lupus who do not fulfill classification criteria for SLE. Some patients with iSLE have persistent mild disease, but others have serious organ involvement, and up to 55% progress to established SLE. Research on this subject could reveal predictive or diagnostic biomarkers for SLE. Ideally, it would become possible to discern those patients with critical organ involvement or a high risk for progression to SLE. This high‐risk group might benefit from early treatment, which would preferably be confirmed in randomized controlled trials. This process would, however, require agreement on a definition of iSLE. The Systemic Lupus International Collaborating Clinics (SLICC) classification criteria was composed in order to diagnose SLE earlier. The present review outlines the clinical characteristics of iSLE after introduction of SLICC criteria and furthermore proposes a definition of iSLE with the aim of discriminating the high‐risk group from those with a lower risk.
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No potential conflicts of interest relevant to this article were reported.
Supported by the Dutch Arthritis Foundation.
Wietske M. Lambers, MD, Johanna Westra, PhD, Marcel F. Jonkman, MD, PhD, Hendrika Bootsma, MD, PhD, Karina de Leeuw, MD, PhD: University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
ISSN:2151-464X
2151-4658
2151-4658
DOI:10.1002/acr.23894