Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic
Hepatocellular carcinoma is a malignant tumor with high morbidity and mortality, a highly effective treatment with low side effects and tolerance is needed. Photothermal immunotherapy is a promising treatment combining photothermal therapy (PTT) and immunotherapy. PTT induces the release of tumor-as...
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| Published in | Frontiers in pharmacology Vol. 12; p. 648708 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Frontiers Media S.A
06.07.2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1663-9812 1663-9812 |
| DOI | 10.3389/fphar.2021.648708 |
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| Abstract | Hepatocellular carcinoma is a malignant tumor with high morbidity and mortality, a highly effective treatment with low side effects and tolerance is needed. Photothermal immunotherapy is a promising treatment combining photothermal therapy (PTT) and immunotherapy. PTT induces the release of tumor-associated antigens by ablating tumor and Ganoderma lucidum polysaccharides (GLP) enhance the antitumor immunity. Results showed that Indocyanine Green (ICG) was successfully encapsulated into SF-Gel. ICG could convert light to heat and SF-Gel accelerates the photothermal effect
in vitro
and
in vivo
. PTT based on ICG/ICG-SF-Gel inhibited the growth of primary and distal tumors, GLP enhanced the inhibitory efficacy. ICG/ICG-SF-Gel-based PTT and GLP immunotherapy improved the survival time. ICG/ICG-SF-Gel-based PTT induces tumor necrosis and GLP enhanced the photothermal efficacy. ICG/ICG-SF-Gel-based PTT inhibited cell proliferation and angiogenesis, induced cell apoptosis, enhanced cellular immunity, and GLP enhanced these effects. In conclusion, GLP could enhance the abscopal effect of PTT in Hepatoma-bearing mice. |
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| AbstractList | Hepatocellular carcinoma is a malignant tumor with high morbidity and mortality, a highly effective treatment with low side effects and tolerance is needed. Photothermal immunotherapy is a promising treatment combining photothermal therapy (PTT) and immunotherapy. PTT induces the release of tumor-associated antigens by ablating tumor and Ganoderma lucidum polysaccharides (GLP) enhance the antitumor immunity. Results showed that Indocyanine Green (ICG) was successfully encapsulated into SF-Gel. ICG could convert light to heat and SF-Gel accelerates the photothermal effect
in vitro
and
in vivo
. PTT based on ICG/ICG-SF-Gel inhibited the growth of primary and distal tumors, GLP enhanced the inhibitory efficacy. ICG/ICG-SF-Gel-based PTT and GLP immunotherapy improved the survival time. ICG/ICG-SF-Gel-based PTT induces tumor necrosis and GLP enhanced the photothermal efficacy. ICG/ICG-SF-Gel-based PTT inhibited cell proliferation and angiogenesis, induced cell apoptosis, enhanced cellular immunity, and GLP enhanced these effects. In conclusion, GLP could enhance the abscopal effect of PTT in Hepatoma-bearing mice. Hepatocellular carcinoma is a malignant tumor with high morbidity and mortality, a highly effective treatment with low side effects and tolerance is needed. Photothermal immunotherapy is a promising treatment combining photothermal therapy (PTT) and immunotherapy. PTT induces the release of tumor-associated antigens by ablating tumor and Ganoderma lucidum polysaccharides (GLP) enhance the antitumor immunity. Results showed that Indocyanine Green (ICG) was successfully encapsulated into SF-Gel. ICG could convert light to heat and SF-Gel accelerates the photothermal effect in vitro and in vivo. PTT based on ICG/ICG-SF-Gel inhibited the growth of primary and distal tumors, GLP enhanced the inhibitory efficacy. ICG/ICG-SF-Gel-based PTT and GLP immunotherapy improved the survival time. ICG/ICG-SF-Gel-based PTT induces tumor necrosis and GLP enhanced the photothermal efficacy. ICG/ICG-SF-Gel-based PTT inhibited cell proliferation and angiogenesis, induced cell apoptosis, enhanced cellular immunity, and GLP enhanced these effects. In conclusion, GLP could enhance the abscopal effect of PTT in Hepatoma-bearing mice. Hepatocellular carcinoma is a malignant tumor with high morbidity and mortality, a highly effective treatment with low side effects and tolerance is needed. Photothermal immunotherapy is a promising treatment combining photothermal therapy (PTT) and immunotherapy. PTT induces the release of tumor-associated antigens by ablating tumor and Ganoderma lucidum polysaccharides (GLP) enhance the antitumor immunity. Results showed that Indocyanine Green (ICG) was successfully encapsulated into SF-Gel. ICG could convert light to heat and SF-Gel accelerates the photothermal effect in vitro and in vivo. PTT based on ICG/ICG-SF-Gel inhibited the growth of primary and distal tumors, GLP enhanced the inhibitory efficacy. ICG/ICG-SF-Gel-based PTT and GLP immunotherapy improved the survival time. ICG/ICG-SF-Gel-based PTT induces tumor necrosis and GLP enhanced the photothermal efficacy. ICG/ICG-SF-Gel-based PTT inhibited cell proliferation and angiogenesis, induced cell apoptosis, enhanced cellular immunity, and GLP enhanced these effects. In conclusion, GLP could enhance the abscopal effect of PTT in Hepatoma-bearing mice.Hepatocellular carcinoma is a malignant tumor with high morbidity and mortality, a highly effective treatment with low side effects and tolerance is needed. Photothermal immunotherapy is a promising treatment combining photothermal therapy (PTT) and immunotherapy. PTT induces the release of tumor-associated antigens by ablating tumor and Ganoderma lucidum polysaccharides (GLP) enhance the antitumor immunity. Results showed that Indocyanine Green (ICG) was successfully encapsulated into SF-Gel. ICG could convert light to heat and SF-Gel accelerates the photothermal effect in vitro and in vivo. PTT based on ICG/ICG-SF-Gel inhibited the growth of primary and distal tumors, GLP enhanced the inhibitory efficacy. ICG/ICG-SF-Gel-based PTT and GLP immunotherapy improved the survival time. ICG/ICG-SF-Gel-based PTT induces tumor necrosis and GLP enhanced the photothermal efficacy. ICG/ICG-SF-Gel-based PTT inhibited cell proliferation and angiogenesis, induced cell apoptosis, enhanced cellular immunity, and GLP enhanced these effects. In conclusion, GLP could enhance the abscopal effect of PTT in Hepatoma-bearing mice. |
| Author | Xu, He-Lin Yao, Qing Zhao, Ying-Zheng Zhuge, De-Li Xia, Qing-Hai Yue, Meng Tong, Meng-Qi Lu, Cui-Tao Chen, Rui |
| AuthorAffiliation | Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City , China |
| AuthorAffiliation_xml | – name: Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City , China |
| Author_xml | – sequence: 1 givenname: Qing-Hai surname: Xia fullname: Xia, Qing-Hai – sequence: 2 givenname: Cui-Tao surname: Lu fullname: Lu, Cui-Tao – sequence: 3 givenname: Meng-Qi surname: Tong fullname: Tong, Meng-Qi – sequence: 4 givenname: Meng surname: Yue fullname: Yue, Meng – sequence: 5 givenname: Rui surname: Chen fullname: Chen, Rui – sequence: 6 givenname: De-Li surname: Zhuge fullname: Zhuge, De-Li – sequence: 7 givenname: Qing surname: Yao fullname: Yao, Qing – sequence: 8 givenname: He-Lin surname: Xu fullname: Xu, He-Lin – sequence: 9 givenname: Ying-Zheng surname: Zhao fullname: Zhao, Ying-Zheng |
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| CitedBy_id | crossref_primary_10_1080_0028825X_2024_2375996 crossref_primary_10_1186_s12951_024_02547_9 crossref_primary_10_1016_j_ijbiomac_2025_140820 crossref_primary_10_1016_S1875_5364_24_60558_3 crossref_primary_10_1016_j_ijbiomac_2025_140645 crossref_primary_10_1002_adma_202408511 crossref_primary_10_1016_j_fbio_2025_105990 crossref_primary_10_1186_s13020_023_00811_y crossref_primary_10_3390_cancers17020183 crossref_primary_10_3389_fimmu_2021_792781 |
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| ContentType | Journal Article |
| Copyright | Copyright © 2021 Xia, Lu, Tong, Yue, Chen, Zhuge, Yao, Xu and Zhao. Copyright © 2021 Xia, Lu, Tong, Yue, Chen, Zhuge, Yao, Xu and Zhao. 2021 Xia, Lu, Tong, Yue, Chen, Zhuge, Yao, Xu and Zhao |
| Copyright_xml | – notice: Copyright © 2021 Xia, Lu, Tong, Yue, Chen, Zhuge, Yao, Xu and Zhao. – notice: Copyright © 2021 Xia, Lu, Tong, Yue, Chen, Zhuge, Yao, Xu and Zhao. 2021 Xia, Lu, Tong, Yue, Chen, Zhuge, Yao, Xu and Zhao |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Pharmacology Reviewed by: Bin Yang, Guangzhou Medical University, China Pengfei Zhang, Shenzhen Institutes of Advanced Technology (CAS), China Edited by: Aniello Cerrato, Istituto per l’Endocrinologia e l’oncologia “Gaetano Salvatore (CNR), Italy |
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| SubjectTerms | abscopal effect anti-proliferative ganoderma lucidum polysaccharides hepatoma immunomodulatory Pharmacology photothermal immunotherapy |
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| Title | Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic |
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