Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic

• Published in: Frontiers in pharmacology Vol. 12; p. 648708
• Main Authors: Xia, Qing-Hai, Lu, Cui-Tao, Tong, Meng-Qi, Yue, Meng, Chen, Rui, Zhuge, De-Li, Yao, Qing, Xu, He-Lin, Zhao, Ying-Zheng
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 06.07.2021
• Subjects: abscopal effect; anti-proliferative; ganoderma lucidum polysaccharides; hepatoma; immunomodulatory; Pharmacology; photothermal immunotherapy
• ISSN: 1663-9812; 1663-9812
• DOI: 10.3389/fphar.2021.648708

Hepatocellular carcinoma is a malignant tumor with high morbidity and mortality, a highly effective treatment with low side effects and tolerance is needed. Photothermal immunotherapy is a promising treatment combining photothermal therapy (PTT) and immunotherapy. PTT induces the release of tumor-associated antigens by ablating tumor and Ganoderma lucidum polysaccharides (GLP) enhance the antitumor immunity. Results showed that Indocyanine Green (ICG) was successfully encapsulated into SF-Gel. ICG could convert light to heat and SF-Gel accelerates the photothermal effect in vitro and in vivo . PTT based on ICG/ICG-SF-Gel inhibited the growth of primary and distal tumors, GLP enhanced the inhibitory efficacy. ICG/ICG-SF-Gel-based PTT and GLP immunotherapy improved the survival time. ICG/ICG-SF-Gel-based PTT induces tumor necrosis and GLP enhanced the photothermal efficacy. ICG/ICG-SF-Gel-based PTT inhibited cell proliferation and angiogenesis, induced cell apoptosis, enhanced cellular immunity, and GLP enhanced these effects. In conclusion, GLP could enhance the abscopal effect of PTT in Hepatoma-bearing mice.