MRI measurements predict major low anterior resection syndrome in rectal cancer patients

• Published in: International journal of colorectal disease Vol. 37; no. 6; pp. 1239 - 1249
• Main Authors: Zhang, Xiao-Yan, Liu, Xin-Zhi, Li, Xiao-Ting, Wang, Lin, Zhu, Hai-Bin, Sun, Rui-Jia, Guan, Zhen, Lu, Qiao-Yuan, Zhu, Hai-Tao, Wang, Wei-Hu, Li, Zhong-Wu, Wu, Ai-Wen, Sun, Ying-Shi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2022; Springer; Springer Nature B.V
• Subjects: Cancer patients; Chemoradiotherapy; Chemotherapy; Colorectal cancer; Decision making; Gastroenterology; Hepatology; Internal Medicine; Magnetic resonance imaging; Medical imaging equipment; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Original Article; Patients; Proctology; Quality of life; Radiation therapy; Rectum; Surgery; Tumors; Anal rectal joint; Rectal cancer; Magnetic resonance imaging; Low anterior resection syndrome; Neoadjuvant chemoradiotherapy
• ISSN: 1432-1262; 0179-1958; 1432-1262
• DOI: 10.1007/s00384-022-04169-9

Purpose Current low anterior resection syndrome (LARS) score is lagging behind and only based on clinical symptoms patient described. Preoperative imaging indicators which can be used to predict LARS is unknown. We proposed preoperative MRI parameters for identifying major LARS. Methods Patients receiving curative restorative anterior resection from Sept. 2007 to Sept. 2015 were collected to complete LARS score (median 75.7 months since surgery). MRI measurements associated with LARS were tested, and a multivariate logistic model was conducted for predicting LARS. Receiver operating characteristic curve was used to evaluate the model. Results Two hundred fifty-five patients undergoing neoadjuvant chemoradiotherapy and 72 patients undergoing direct surgery were enrolled. The incidence of major LARS in NCRT group was significantly higher (53.3% vs.34.7%, P  = 0.005). In patients with neoadjuvant chemoradiotherapy, the thickness of ARJ (TARJ), the distance between the tumor’s lower edge and anal rectal joint (DTA), and sex were independent factors for predicting major LARS; ORs were 0.382 (95% CI, 0.198–0.740), 0.653 (95% CI, 0.565–0.756), and 0.935 (95% CI, 0.915–0.955). The AUC of the multivariable model was 0.842 (95% CI, 0.794–0.890). In patients with direct surgery, only DTA was the independent factor for predicting major LARS; OR was 0.958 (95% CI, 0.930–0.988). The AUC was 0.777 (95% CI: 0.630–0.925). Conclusions Baseline MRI measurements have the potential to predict major LARS in rectal cancer, which will benefit the decision-making and improve patients’ life quality.