Stable Incidence and Increasing Prevalence of Primary Hyperparathyroidism in a Population-based Study in Scotland

• Published in: The journal of clinical endocrinology and metabolism Vol. 108; no. 10; pp. e1117 - e1124
• Main Authors: Soto-Pedre, Enrique, Newey, Paul J, Leese, Graham P
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 18.09.2023
• Subjects: Aged; Clinical; Demography; Female; Follow-Up Studies; Humans; Hyperparathyroidism; Hyperparathyroidism, Primary - surgery; Incidence; Male; Parathyroid Hormone; Parathyroidectomy; Patient admissions; Population studies; Population-based studies; Prevalence; Retrospective Studies; Scotland - epidemiology; Scotland; United Kingdom > UK; epidemiology; prevalence; primary hyperparathyroidism; parathyroid gland; incidence
• ISSN: 0021-972X; 1945-7197; 1945-7197
• DOI: 10.1210/clinem/dgad201

Abstract Context Previous studies, including our own, have demonstrated a highly variable incidence of primary hyperparathyroidism (PHPT) from year to year. Objective We planned to provide a current estimate of the incidence and prevalence of PHPT in a community-based study. Methods A population-based retrospective follow-up study was conducted in Tayside (Scotland) from 2007 to 2018. Record-linkage technology (demography, biochemistry, prescribing, hospital admissions, radiology, and mortality data) was used to identify all patients. Cases of PHPT were defined as those with at least 2 raised serum corrected calcium concentration CCA (> 2.55 mmol/L) and/or hospital admissions with PHPT diagnoses and/or surgery records with parathyroidectomy during the follow-up period. The number of prevalent and incident cases of PHPT per calendar year by age and sex were estimated. Results A total of 2118 people (72.3% female, mean age 65 years) were identified with an incident case of PHPT. The overall prevalence of PHPT over the 12 years of the study was 0.84% (95% CI, 0.68%-1.02%), steadily increasing from 0.71% in 2007 to 1.02% in 2018. From 2008, the incidence of PHPT was relatively stable from 4 to 6 cases per 10 000 person-years, declining from 11.5 per 10 000 person-years in 2007. The incidence varied from 0.59 per 10 000 person-years (95% CI, 0.40%-0.77%) for those aged 20 to 29 years, to 12.4 per 10 000 person-years (95% CI, 11.2%-13.3%) in those aged 70 to 79 years. Incidence of PHPT was 2.5 times higher in women than in men. Conclusion This study is the first showing a relatively steady annual incidence of PHPT at 4 to 6 per 10 000 person-years. This population-based study reports a PHPT prevalence of 0.84%.