Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles
•This paper discusses in detail the prospective ways to use various existing treatment modalities to enhance the EPR effect.•The article also focuses on the active and passive targeting and the mechanism by which they target to improve the EPR effect.•This article describes a range of recently desig...
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| Published in | Photodiagnosis and photodynamic therapy Vol. 39; p. 102915 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.09.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1572-1000 1873-1597 1873-1597 |
| DOI | 10.1016/j.pdpdt.2022.102915 |
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| Abstract | •This paper discusses in detail the prospective ways to use various existing treatment modalities to enhance the EPR effect.•The article also focuses on the active and passive targeting and the mechanism by which they target to improve the EPR effect.•This article describes a range of recently designed nanoformulations reported to exhibit enhanced EPR effect.•A special focus has been given on combination therapy for in vitro or in vivo studies that help in achieving a synergistic EPR effect.
Exploring the enhanced permeability and retention (EPR) effect through therapeutic nanoparticles has been a subject of considerable interest in tumor biology. This passive targeting based phenomenon exploits the leaky blood vasculature and the defective lymphatic drainage system of the heterogeneous tumor microenvironment resulting in enhanced preferential accumulation of the nanoparticles within the tumor tissues. This article reviews the fundamental studies to assess how the EPR effect plays an essential role in passive targeting. Further, it summarizes various therapeutic modalities of nanoformulation including chemo-photodynamic therapy, intravascular drug release, and photothermal immunotherapy to combat cancer using enhanced EPR effect in neoplasia region. |
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| AbstractList | Exploring the enhanced permeability and retention (EPR) effect through therapeutic nanoparticles has been a subject of considerable interest in tumor biology. This passive targeting based phenomenon exploits the leaky blood vasculature and the defective lymphatic drainage system of the heterogeneous tumor microenvironment resulting in enhanced preferential accumulation of the nanoparticles within the tumor tissues. This article reviews the fundamental studies to assess how the EPR effect plays an essential role in passive targeting. Further, it summarizes various therapeutic modalities of nanoformulation including chemo-photodynamic therapy, intravascular drug release, and photothermal immunotherapy to combat cancer using enhanced EPR effect in neoplasia region.Exploring the enhanced permeability and retention (EPR) effect through therapeutic nanoparticles has been a subject of considerable interest in tumor biology. This passive targeting based phenomenon exploits the leaky blood vasculature and the defective lymphatic drainage system of the heterogeneous tumor microenvironment resulting in enhanced preferential accumulation of the nanoparticles within the tumor tissues. This article reviews the fundamental studies to assess how the EPR effect plays an essential role in passive targeting. Further, it summarizes various therapeutic modalities of nanoformulation including chemo-photodynamic therapy, intravascular drug release, and photothermal immunotherapy to combat cancer using enhanced EPR effect in neoplasia region. •This paper discusses in detail the prospective ways to use various existing treatment modalities to enhance the EPR effect.•The article also focuses on the active and passive targeting and the mechanism by which they target to improve the EPR effect.•This article describes a range of recently designed nanoformulations reported to exhibit enhanced EPR effect.•A special focus has been given on combination therapy for in vitro or in vivo studies that help in achieving a synergistic EPR effect. Exploring the enhanced permeability and retention (EPR) effect through therapeutic nanoparticles has been a subject of considerable interest in tumor biology. This passive targeting based phenomenon exploits the leaky blood vasculature and the defective lymphatic drainage system of the heterogeneous tumor microenvironment resulting in enhanced preferential accumulation of the nanoparticles within the tumor tissues. This article reviews the fundamental studies to assess how the EPR effect plays an essential role in passive targeting. Further, it summarizes various therapeutic modalities of nanoformulation including chemo-photodynamic therapy, intravascular drug release, and photothermal immunotherapy to combat cancer using enhanced EPR effect in neoplasia region. Exploring the enhanced permeability and retention (EPR) effect through therapeutic nanoparticles has been a subject of considerable interest in tumor biology. This passive targeting based phenomenon exploits the leaky blood vasculature and the defective lymphatic drainage system of the heterogeneous tumor microenvironment resulting in enhanced preferential accumulation of the nanoparticles within the tumor tissues. This article reviews the fundamental studies to assess how the EPR effect plays an essential role in passive targeting. Further, it summarizes various therapeutic modalities of nanoformulation including chemo-photodynamic therapy, intravascular drug release, and photothermal immunotherapy to combat cancer using enhanced EPR effect in neoplasia region. |
| ArticleNumber | 102915 |
| Author | Singh, Surya Prakash Rengan, Aravind Kumar Murugappan, Sivasubramanian Shinde, Vinod Ravasaheb Revi, Neeraja |
| Author_xml | – sequence: 1 givenname: Vinod Ravasaheb surname: Shinde fullname: Shinde, Vinod Ravasaheb organization: Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Telangana, India – sequence: 2 givenname: Neeraja orcidid: 0000-0003-0810-9054 surname: Revi fullname: Revi, Neeraja organization: Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Telangana, India – sequence: 3 givenname: Sivasubramanian surname: Murugappan fullname: Murugappan, Sivasubramanian organization: Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Telangana, India – sequence: 4 givenname: Surya Prakash surname: Singh fullname: Singh, Surya Prakash organization: Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Telangana, India – sequence: 5 givenname: Aravind Kumar orcidid: 0000-0003-3994-6760 surname: Rengan fullname: Rengan, Aravind Kumar email: aravind@bme.iith.ac.in organization: Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Telangana, India |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35597441$$D View this record in MEDLINE/PubMed |
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| Keywords | Nanoparticles PTT PDT Microbubble EPR Extravasation Microenvironment Photodynamic Therapy Pharmacokinetics Ultrasound Enhanced Permeability and Retention (EPR) effect |
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| Title | Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles |
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