Arterial stiffness is not associated with changes in the circadian pattern of blood pressure in patients with type 1 diabetes mellitus and cardiovascular autonomic dysfunction

• Published in: Diabetes & vascular disease research Vol. 20; no. 3; p. 14791641231173621
• Main Authors: Nattero-Chávez, Lía, Bayona Cebada, Ane, Fernández-Durán, Elena, Quintero Tobar, Alejandra, Dorado Avendaño, Beatriz, Escobar-Morreale, Héctor, Luque-Ramírez, Manuel
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.05.2023
• Subjects: Adult; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm - physiology; Cross-Sectional Studies; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - diagnosis; Humans; Hypertension - diagnosis; Middle Aged; Original; Risk Factors; Vascular Stiffness - physiology; non-dipping; type 1 diabetes; Arterial stiffness; cardiovascular autonomic neuropathy
• ISSN: 1479-1641; 1752-8984; 1752-8984
• DOI: 10.1177/14791641231173621

Introduction Cardiovascular autonomic neuropathy (CAN) associates an abnormal circadian pattern in blood pressure (BP) regulation that might be aggravated by the coexistence of arterial stiffness. We aimed to evaluate the effect of arterial stiffness in the circadian rhythm of BP in patients with type 1 diabetes and CAN. Methods Cross-sectional study including 56 consecutive patients with type 1 diabetes and CAN, with (n = 28) or without (n = 24) arterial stiffness as defined by an ankle-brachial index above 1.2. CAN was diagnosed by BP and heart rate responses to active standing and cardiovascular autonomic reflex tests. Absence of nocturnal decrease in BP–“non-dipping” pattern– was defined by a daytime to nighttime decrease in mean BP smaller than 10%. Results The study’s subjects mean age was 40 ± 11 years-old, their mean duration of diabetes was 22 ± 10 years, and their mean A1c was 7.9 ± 1.5%. A “non-dipping” pattern was observed in 28 patients (54%) regardless of the presence or absence of arterial stiffness. Age, waist circumference, body mass index, and A1c, were introduced as independent variables into a multiple regression analysis. The stepwise model (R2: 0.113, p = 0.016) retained only A1c levels (β: ‒ 0.333, 95% confidence interval [CI]: −3.10 to −0.33) as significant predictor of the percentage of nighttime decrease in mean BP. Conclusions A non-dipping pattern in BP is very common in patients with type 1 diabetes presenting with subclinical CAN and is associated with a poorer metabolic control. On the contrary, coexistence of arterial stiffness is not associated with abnormalities in circadian BP regulation.