Increased circulating intercellular adhesion molecule-1 levels in type II diabetic patients: The possible role of metabolic control and oxidative stress

• Published in: Metabolism, clinical and experimental Vol. 45; no. 4; pp. 498 - 501
• Main Authors: Ceriello, Antonio, Falleti, Edmondo, Bortolotti, Nadia, Motz, Enrico, Cavarape, Alessandro, Russo, Assunta, Gonano, Fabio, Bartoli, Ettore
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.1996; Elsevier
• Subjects: analysis; Associated diseases and complications; Biological and medical sciences; blood; BLOOD CHEMISTRY; BLOOD COMPOSITION; BLOOD LIPIDS; COMPOSICION DE LA SANGRE; COMPOSITION DU SANG; CORRELATION; DIABETE; DIABETES; diabetes mellitus type ii; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; ENFERMEDADES VASCULARES; ESTRES; Female; GENERO HUMANO; GENRE HUMAIN; Glucose; Glucose - metabolism; Glycated Hemoglobin; Glycated Hemoglobin A - analysis; glycohemoglobin; HAEMOGLOBIN; HEMOGLOBIN A1; hemoglobin a1c; HEMOGLOBINA; HEMOGLOBINE; HEMOLIPIDOS; Humans; INFLAMACION; INFLAMMATION; integrin; Intercellular Adhesion Molecule-1; Intercellular Adhesion Molecule-1 - blood; LIPIDE SANGUIN; macroangiopathy; MALADIE VASCULAIRE; Male; malondialdehyde; Malondialdehyde - blood; MANKIND; Medical sciences; METABOLISM; METABOLISME; METABOLISMO; METHODE STATISTIQUE; METODOS ESTADISTICOS; Middle Aged; MULTIPLE REGRESSION; noninsulin-dependent diabetes mellitus; OXIDACION; OXIDATION; Oxidative Stress; Oxidative Stress - physiology; OXYDATION; physiology; physiopathology; Regression Analysis; STATISTICAL METHODS; STRESS; VASCULAR DISEASES; Endocrinopathy; Human; Oxidative stress; Pathophysiology; Pathogenesis; Cell adhesion molecule; Inflammation; Metabolism; Non insulin dependent diabetes; Equilibrium; Hemoglobin A1c; Complication; intercellular adhesion; Glycemia
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/S0026-0495(96)90226-7

Blood levels of the circulating form of the integrin intercellular adhesion molecule-1 (ICAM-1), malondialdehyde (MDA), and hemoglobin A 1c(HbA 1c) were studied at baseline and 3 months after improved metabolic control in 25 type II diabetic patients without signs of macroangiopathy, and were compared with those in 15 matched healthy normal controls. Circulating ICAM-1 and MDA levels were increased in diabetic patients, both at baseline and 3 months later. However, with improving metabolic control HbA 1c, circulating ICAM-1, and MDA significantly decreased. A significant correlation between circulating ICAM-1, HbA 1c, and MDA was found in diabetic patients at each time. Multiple regression analysis considering circulating ICAM-1 as the dependent variable and HbA 1c and MDA as independent variables, showed a significant correlation between the three variables at each time. Similar correlations were found in control subjects. These data show increased levels of circulating ICAM-1 in type II diabetic patients, independent of the presence of macroangiopathy. Moreover, these results suggest that oxidative stress and metabolic control might participate in determining increased circulating ICAM-1 levels in both type II diabetic patients and normal subjects.