Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter

• Published in: Biomolecules & therapeutics Vol. 27; no. 6; pp. 562 - 569
• Main Authors: Zhen, Ao Xuan, Piao, Mei Jing, Kang, Kyoung Ah, Fernando, Pincha Devage Sameera Madushan, Kang, Hee Kyoung, Koh, Young Sang, Yi, Joo Mi, Hyun, Jin Won
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Applied Pharmacology 01.11.2019; 한국응용약물학회
• Subjects: Original; 약학; Niacinamide; Oxidative stress; Human HaCaT keratinocyte; Particulate matter 2.5
• ISSN: 1976-9148; 2005-4483; 2005-4483
• DOI: 10.4062/biomolther.2019.061

Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that particulate matter 2.5 (PM ) induced reactive oxygen species (ROS), causing disruption of DNA, lipids, and proteins; mitochondrial depolarization, and apoptosis of skin keratinocytes. Here, we investigated the protective effects of NIA on PM -induced oxidative stress in human HaCaT keratinocytes. We found that NIA could inhibit the ROS generation induced by PM , as well blocked the PM -induced oxidation of molecules, such as lipids, proteins, and DNA. Furthermore, NIA alleviated PM -induced accumulation of cellular Ca , which caused cell membrane depolarization and apoptosis, and reduced the number of apoptotic cells. Collectively, the findings show that NIA can protect keratinocytes from PM -induced oxidative stress and cell damage.