Loss of 14q Chromosome in Oligodendroglial and Astrocytic Tumors

• Published in: Journal of neuro-oncology Vol. 67; no. 3; pp. 281 - 285
• Main Authors: Dichamp, Charles, Taillibert, Sophie, Aguirre-Cruz, Lucinda, Lejeune, Julie, Marie, Yannick, Kujas, Michèle, Delattre, Jean-Yves, Hoang-Xuan, Khe, Sanson, Marc
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.05.2004; Springer Nature B.V
• Subjects: Astrocytoma - genetics; Astrocytoma - pathology; Biological and medical sciences; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Chromosomes, Human, Pair 14 - genetics; DNA, Neoplasm - genetics; Genes, erbB-1 - genetics; Genes, p16 - physiology; Genes, p53 - genetics; Humans; Loss of Heterozygosity; Medical sciences; Microsatellite Repeats; Neoplasm Staging; Neurology; Oligodendroglioma - genetics; Oligodendroglioma - pathology; Phosphoric Monoester Hydrolases - genetics; Survival Rate; Malignant glioma; Nervous system diseases; Central nervous system disease; Glioblastoma; Chromosome; chromosome 14q; glioma; Malignant tumor; Oligodendroglioma
• ISSN: 0167-594X; 1573-7373
• DOI: 10.1023/B:NEON.0000024218.68120.8d

Loss of chromosome 14q has been investigated in 142 gliomas. Loss of heterozygosity (LOH) at one or more microsatellite has been found in 8/30 grade II (27%) and 2/21 grade III (10%) oligodendrogliomas, 3/9 grade II (33%) and 5/15 grade III (33%) oligoastrocytomas, 0/9 grade II (0%) and 1/7 grade III (14%) astrocytomas, 11/51 glioblastomas (22%). Two minimal regions were identified on 14q21.2-14q24.3 (between D14S288 and D14S74) and 14q31.3-14q32.1 (between D14S74 and D14S65). Loss of 14q was not correlated to survival, histological grading and subtype or other genetic alterations, except for 1p deletions. Taken together, these data suggest that LOH14q is an early alteration involving 20% of glioma.