Microswimmers learning chemotaxis with genetic algorithms

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 19; pp. 1 - 7
• Main Authors: Hartl, Benedikt, Hübl, Maximilian, Kahl, Gerhard, Zöttl, Andreas
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.05.2021
• Subjects: Algorithms; Animals; Applied Physical Sciences; Artificial neural networks; Body fluids; Caenorhabditis elegans - physiology; Chemotaxis; Chemotaxis - genetics; Chemotaxis - physiology; Computational fluid dynamics; Computational neuroscience; Computer Simulation; Decision making; Deformation; Flagella; Flagella - physiology; Genetic algorithms; Learning - physiology; Machine Learning; Mammalian cells; Mammals; Microorganisms; Models, Biological; Motion; Nervous system; Neural networks; Neural Networks, Computer; Nutrients; Physical Sciences; Rotating bodies; Signal transmission; Swimming; Swimming - physiology; Topology; Viscous fluids; genetic algorithm; low-Reynolds number swimming; machine learning; neural network; chemotaxis
• ISSN: 0027-8424; 1091-6490; 1091-6490
• DOI: 10.1073/pnas.2019683118

Various microorganisms and some mammalian cells are able to swim in viscous fluids by performing nonreciprocal body deformations, such as rotating attached flagella or by distorting their entire body. In order to perform chemotaxis (i.e., to move toward and to stay at high concentrations of nutrients), they adapt their swimming gaits in a nontrivial manner. Here, we propose a computational model, which features autonomous shape adaptation of microswimmers moving in one dimension toward high field concentrations. As an internal decision-making machinery, we use artificial neural networks, which control the motion of the microswimmer. We present two methods to measure chemical gradients, spatial and temporal sensing, as known for swimming mammalian cells and bacteria, respectively. Using the genetic algorithm NeuroEvolution of Augmenting Topologies, surprisingly simple neural networks evolve. These networks control the shape deformations of the microswimmers and allow them to navigate in static and complex time-dependent chemical environments. By introducing noisy signal transmission in the neural network, the well-known biased run-and-tumble motion emerges. Our work demonstrates that the evolution of a simple and interpretable internal decision-making machinery coupled to the environment allows navigation in diverse chemical landscapes. These findings are of relevance for intracellular biochemical sensing mechanisms of single cells or for the simple nervous system of small multicellular organisms such as Caenorhabditis elegans.