Effects of Spermidine and p-Cresol on Polymorphonuclear Cell Apoptosis and Function

Polymorphonuclear leukocytes (PMNs) from chronic kidney disease (CKD) patients display accelerated apoptosis and dysfunction, which may predispose CKD patients to infections. In this study, we investigated the effect of spermidine and p‐cresol on apoptosis and function on PMN from healthy subjects....

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Published in	Artificial organs Vol. 35; no. 2; pp. E27 - E32
Main Authors	de Carvalho Jr, Jose Tarcisio G., Dalboni, Maria A., Watanabe, Renato, Peres, Alines T., Goes, Miguel A., Manfredi, Silvia R., Canziani, Maria E., Cendoroglo, Gabriel S., Guimarães-Souza, Nadia, Batista, Marcelo C., Cendoroglo, Miguel
Format	Journal Article
Language	English
Published	Malden, USA Blackwell Publishing Inc 01.02.2011
Subjects	Apoptosis Apoptosis - drug effects CD11b Antigen - immunology Cresols - pharmacology Humans Immune dysfunction Neutrophils - cytology Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Reactive Oxygen Species - metabolism Reactive oxygen species production Spermidine - pharmacology Uremic toxins
Online Access	Get full text
ISSN	0160-564X 1525-1594 1525-1594
DOI	10.1111/j.1525-1594.2010.01116.x

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Abstract	Polymorphonuclear leukocytes (PMNs) from chronic kidney disease (CKD) patients display accelerated apoptosis and dysfunction, which may predispose CKD patients to infections. In this study, we investigated the effect of spermidine and p‐cresol on apoptosis and function on PMN from healthy subjects. We measured the effect of spermidine and p‐cresol on apoptosis, ROS production unstimulated and stimulated (S. aureus and PMA) and expression of CD95, caspase 3, and CD11b on PMN. After incubation with p‐cresol and spermidine, we did not observe any changes in apoptosis, viability or expression of caspase 3 and CD95 in PMN from healthy subjects. PMN incubated for 10 minutes with spermidine demonstrated a significant reduction in spontaneous, S. aureus and PMA‐stimulated ROS production. p‐cresol induced a decrease in PMA‐stimulated ROS production. Spermidine and p‐cresol also induced a decrease in the expression of CD11b on PMN. Spermidine and p‐cresol decreased the expression of CD11b and oxidative burst of PMN from healthy subjects and had no effect on PMN apoptosis and viability.
AbstractList	Polymorphonuclear leukocytes (PMNs) from chronic kidney disease (CKD) patients display accelerated apoptosis and dysfunction, which may predispose CKD patients to infections. In this study, we investigated the effect of spermidine and p-cresol on apoptosis and function on PMN from healthy subjects. We measured the effect of spermidine and p-cresol on apoptosis, ROS production unstimulated and stimulated (S. aureus and PMA) and expression of CD95, caspase 3, and CD11b on PMN. After incubation with p-cresol and spermidine, we did not observe any changes in apoptosis, viability or expression of caspase 3 and CD95 in PMN from healthy subjects. PMN incubated for 10 minutes with spermidine demonstrated a significant reduction in spontaneous, S. aureus and PMA-stimulated ROS production. p-cresol induced a decrease in PMA-stimulated ROS production. Spermidine and p-cresol also induced a decrease in the expression of CD11b on PMN. Spermidine and p-cresol decreased the expression of CD11b and oxidative burst of PMN from healthy subjects and had no effect on PMN apoptosis and viability. Polymorphonuclear leukocytes (PMNs) from chronic kidney disease (CKD) patients display accelerated apoptosis and dysfunction, which may predispose CKD patients to infections. In this study, we investigated the effect of spermidine and p‐cresol on apoptosis and function on PMN from healthy subjects. We measured the effect of spermidine and p‐cresol on apoptosis, ROS production unstimulated and stimulated ( S. aureus and PMA) and expression of CD95, caspase 3, and CD11b on PMN. After incubation with p‐cresol and spermidine, we did not observe any changes in apoptosis, viability or expression of caspase 3 and CD95 in PMN from healthy subjects. PMN incubated for 10 minutes with spermidine demonstrated a significant reduction in spontaneous, S. aureus and PMA‐stimulated ROS production. p‐cresol induced a decrease in PMA‐stimulated ROS production. Spermidine and p‐cresol also induced a decrease in the expression of CD11b on PMN. Spermidine and p‐cresol decreased the expression of CD11b and oxidative burst of PMN from healthy subjects and had no effect on PMN apoptosis and viability. Polymorphonuclear leukocytes (PMNs) from chronic kidney disease (CKD) patients display accelerated apoptosis and dysfunction, which may predispose CKD patients to infections. In this study, we investigated the effect of spermidine and p-cresol on apoptosis and function on PMN from healthy subjects. We measured the effect of spermidine and p-cresol on apoptosis, ROS production unstimulated and stimulated (S. aureus and PMA) and expression of CD95, caspase 3, and CD11b on PMN. After incubation with p-cresol and spermidine, we did not observe any changes in apoptosis, viability or expression of caspase 3 and CD95 in PMN from healthy subjects. PMN incubated for 10 minutes with spermidine demonstrated a significant reduction in spontaneous, S. aureus and PMA-stimulated ROS production. p-cresol induced a decrease in PMA-stimulated ROS production. Spermidine and p-cresol also induced a decrease in the expression of CD11b on PMN. Spermidine and p-cresol decreased the expression of CD11b and oxidative burst of PMN from healthy subjects and had no effect on PMN apoptosis and viability.Polymorphonuclear leukocytes (PMNs) from chronic kidney disease (CKD) patients display accelerated apoptosis and dysfunction, which may predispose CKD patients to infections. In this study, we investigated the effect of spermidine and p-cresol on apoptosis and function on PMN from healthy subjects. We measured the effect of spermidine and p-cresol on apoptosis, ROS production unstimulated and stimulated (S. aureus and PMA) and expression of CD95, caspase 3, and CD11b on PMN. After incubation with p-cresol and spermidine, we did not observe any changes in apoptosis, viability or expression of caspase 3 and CD95 in PMN from healthy subjects. PMN incubated for 10 minutes with spermidine demonstrated a significant reduction in spontaneous, S. aureus and PMA-stimulated ROS production. p-cresol induced a decrease in PMA-stimulated ROS production. Spermidine and p-cresol also induced a decrease in the expression of CD11b on PMN. Spermidine and p-cresol decreased the expression of CD11b and oxidative burst of PMN from healthy subjects and had no effect on PMN apoptosis and viability.
Author	Manfredi, Silvia R. Peres, Alines T. de Carvalho Jr, Jose Tarcisio G. Guimarães-Souza, Nadia Cendoroglo, Miguel Goes, Miguel A. Dalboni, Maria A. Watanabe, Renato Canziani, Maria E. Cendoroglo, Gabriel S. Batista, Marcelo C.
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Snippet	Polymorphonuclear leukocytes (PMNs) from chronic kidney disease (CKD) patients display accelerated apoptosis and dysfunction, which may predispose CKD patients...
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SubjectTerms	Apoptosis Apoptosis - drug effects CD11b Antigen - immunology Cresols - pharmacology Humans Immune dysfunction Neutrophils - cytology Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Reactive Oxygen Species - metabolism Reactive oxygen species production Spermidine - pharmacology Uremic toxins
Title	Effects of Spermidine and p-Cresol on Polymorphonuclear Cell Apoptosis and Function
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