Development of Anti-Inflammatory Agents Utilizing DC-SIGN Mediated IL-10 Secretion in Autoimmune and Immune-Mediated Disorders: Bridging Veterinary and Human Health

• Published in: International journal of molecular sciences Vol. 26; no. 5; p. 2329
• Main Authors: Baek, Hayeon, Yang, Seung-Woo, Kim, Seulki, Lee, Yunseok, Park, Hwi, Park, Min, Jeon, Byung-Ju, Park, Hanwool, Hwang, Han-Sung, Kim, Joon-Young, Kim, Jung-Hyun, Kang, Young-Sun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2025; MDPI
• Subjects: Analysis; Animals; Anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Anti-inflammatory drugs; Antigen presenting cells; Antigens; Arthritis; Autoimmune diseases; Autoimmune Diseases - drug therapy; Autoimmune Diseases - immunology; Autoimmune Diseases - metabolism; Autoimmune Diseases - veterinary; Carbohydrates; Cell Adhesion Molecules - metabolism; Cytokines; Dendritic cells; Development and progression; Health aspects; HIV; Homeostasis; Human immunodeficiency virus; Humans; Immune system; Infections; Inflammation; Inflammatory bowel disease; Inflammatory diseases; Integrins; Interleukin-10 - metabolism; Lectins; Lectins, C-Type - metabolism; Leprosy; Ligands; Lymphatic system; Lymphocytes; Microbiota; Molecules; Pathogens; Receptors, Cell Surface - metabolism; Review; Rheumatoid arthritis; Rheumatoid factor; Sepsis; Transplants & implants; Tuberculosis; Veterinary medicine; South Korea; Washington, D.C; DC-SIGN ligands; comparative medicine; veterinary autoimmune diseases; DC-SIGN; veterinary immune-mediated diseases; anti-inflammatory effects; translational research; DC-SIGN homologues in animals; IL-10
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms26052329

DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) is a C-type lectin receptor expressed on dendritic cells and M2 macrophages, playing a key role in immune regulation and pathogen recognition. Its ability to mediate anti-inflammatory effects by interacting with specific ligands triggers pathways that suppress pro-inflammatory responses and promote tissue repair, making it a potential therapeutic target for inflammatory and autoimmune diseases. DC-SIGN homologs in various animal species share structural similarities and perform comparable immune functions, offering valuable insights into its broader application across species. By recognizing carbohydrate ligands on pathogens, DC-SIGN facilitates immune modulation, which can be harnessed for developing therapies aimed at controlling inflammation. In veterinary medicine, autoimmune and inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease, represent significant challenges, and the anti-inflammatory properties of DC-SIGN could provide new therapeutic options to improve disease management and enhance animal health. Future investigations should focus on the structural and functional analysis of DC-SIGN homologs in various species, as well as the development of preclinical models to translate these findings into clinical interventions bridging veterinary and human health.