Effect of Maotai liquor on P53 gene in primary hepatocellular carcinoma induced by compound factors in rats

• Published in: Chinese medical journal Vol. 127; no. 2; pp. 378 - 380
• Main Authors: Zhao, Xueke, Cheng, Mingliang, Mu, Mao, Liu, Junling, He, Chang, Zhang, Quan
• Format: Journal Article
• Language: English
• Published: China Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550004, China%Department of Pathology, Guiyang Medicat College, Guiyang,Guizhou 550004, China 2014
• Subjects: Alcoholic Beverages - adverse effects; Animals; Carcinoma, Hepatocellular - metabolism; Gene Expression Regulation, Neoplastic - drug effects; Immunohistochemistry; Liver Neoplasms - metabolism; Male; P53基因; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53 - metabolism; 原发性肝癌; 原发性肝细胞癌; 复合; 大鼠; 流行病学调查; 病毒性肝炎; 酱香型白酒; Maotai liquor; primary hepatocellular carcinoma; P53
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20131138

In China, the morbidity of alcoholic liver diseases （ALD） is increasing, which is the second cause of liver diseases after viral hepatitis. An epidemiological survey of 99 subjects in Kweichow Maotai Distillery who have drunk a lot of Maotai liquor for a long time showed that fatty livers were predominate and the incidence of hepatic fibrosis and cirrhosis was relatively low. Now, we carried out an animal experiment to investigate the mutation of P53 gene in liver tissues of primary hepatocellular carcinoma （HCC） induced by compound factors.