Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney
Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed...
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| Published in | Biochemical and biophysical research communications Vol. 283; no. 2; pp. 417 - 422 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
04.05.2001
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0006-291X 1090-2104 |
| DOI | 10.1006/bbrc.2001.4774 |
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| Abstract | Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and α-ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters. |
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| AbstractList | Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and α-ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters. Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and alpha-ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters. Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and alpha-ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters.Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and alpha-ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters. Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and alpha -ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters. Copyright 2001 Academic Press. |
| Author | Wu, Rong Rong Erion, Mark D. Sun, William van Poelje, Paul D. |
| Author_xml | – sequence: 1 givenname: William surname: Sun fullname: Sun, William – sequence: 2 givenname: Rong Rong surname: Wu fullname: Wu, Rong Rong – sequence: 3 givenname: Paul D. surname: van Poelje fullname: van Poelje, Paul D. – sequence: 4 givenname: Mark D. surname: Erion fullname: Erion, Mark D. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11327718$$D View this record in MEDLINE/PubMed |
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| Keywords | kidney transport membrane transport organic anion liver transport p-aminohippurate |
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| Snippet | Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat... |
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| SubjectTerms | a-ketoglutarate Amino Acid Sequence Animals Anion Transport Proteins Carrier Proteins - genetics Carrier Proteins - isolation & purification Carrier Proteins - metabolism Cell Line Cloning, Molecular Cyclic AMP - metabolism DNA, Complementary - genetics DNA, Complementary - isolation & purification Female fluorescein hOAT1 gene hOAT2 gene hOAT3 gene hOAT4 gene hOAT5 gene Humans In Vitro Techniques Ketoglutaric Acids - metabolism Kidney - metabolism kidney transport Liver - metabolism liver transport membrane transport methotrexate Methotrexate - metabolism Molecular Sequence Data Oocytes - metabolism organic anion Organic Anion Transporters Organic Anion Transporters, Sodium-Independent p-aminohippurate p-Aminohippuric Acid - metabolism Rats RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Homology, Amino Acid Species Specificity Transfection Xenopus laevis |
| Title | Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney |
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