Platelet activating factor: A potential biomarker in acute coronary syndrome?

• Published in: Cardiovascular therapeutics Vol. 35; no. 1; pp. 64 - 70
• Main Authors: Palur Ramakrishnan, Anand Vijaya Kumar, Varghese, Treesa P., Vanapalli, Sreedevi, Nair, Narayanan K., Mingate, Menge Denis
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2017
• Subjects: Acute coronary syndrome; Acute Coronary Syndrome - blood; Acute Coronary Syndrome - diagnosis; Acute coronary syndromes; Animals; Biomarkers - blood; Blood platelets; Blood Platelets - metabolism; Circulatory system; Endothelial dysfunction; Humans; Inflammation; Inflammation Mediators - blood; Oxidative and nitrosative stress; Platelet activating factor; Platelet Activating Factor - metabolism; Platelet Activation; Platelet reactivity; Predictive Value of Tests; Prognosis; Signal Transduction; Endothelial dysfunction; Oxidative and nitrosative stress; Inflammation; Acute coronary syndrome; Platelet reactivity; Platelet activating factor
• ISSN: 1755-5914; 1755-5922
• DOI: 10.1111/1755-5922.12233

Summary Platelet activating factor (PAF) is a potent pro‐inflammatory negotiator that shows distinct spectrum of biological and pharmacological effects. Importantly, it participates in a wide range of pathophysiological conditions. In cardiovascular system, PAF has been shown to have an important role in platelet and neutrophil aggregation, vascular permeability, microvascular leakage, thrombus formation, leukocyte adhesion to the endothelial cells, and initiation and progression of atherosclerosis. The purpose of this article was to review the PAF, a family of lipids that is associated with the pathology of coronary artery diseases due to their association with leading etiological mechanisms such as inflammation, endothelial dysfunction, oxidative and nitrosative stress, and platelet reactivity. This review further provides information about PAF and its potential role as a key contributor to the pathogenesis of cardiovascular disorders.