Isoeugenol is an important contact allergen: can it be safely replaced with isoeugenyl acetate?
The prevalence of contact allergy to the fragrance mix in individuals with eczema is up to 10%. Within the mix, isoeugenol (CAS 97–54–1) is an important individual allergen. Until May 1998, the IFRA (International Fragrance Assocation) guidelines suggested that isoeugenol could safely be used at a l...
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Published in | Contact dermatitis Vol. 41; no. 5; pp. 272 - 275 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.11.1999
Blackwell |
Subjects | |
Online Access | Get full text |
ISSN | 0105-1873 1600-0536 |
DOI | 10.1111/j.1600-0536.1999.tb06160.x |
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Summary: | The prevalence of contact allergy to the fragrance mix in individuals with eczema is up to 10%. Within the mix, isoeugenol (CAS 97–54–1) is an important individual allergen. Until May 1998, the IFRA (International Fragrance Assocation) guidelines suggested that isoeugenol could safely be used at a level of 0.2% in consumer products. In May 1998, IFRA recommended that isoeugenol should not be used at a level that exceeds 0.02% in consumer products, but did not provide guidance on allergen substitution. An alternative to isoeugenol, based on aroma and absence of guide‐lines on use, is isoeugenyl acetate (CAS 93–29–8). 155 consecutive subjects were patch tested to isoeugenyl acetate (1.2%, 0.4%, 0.13% eth.) and isoeugenol 1% pet. 6 (3.9%) had an allergic reaction to 1.2% isoeugenyl acetate at D4. The reactions to the other 2 dilutions tended to be graded. 8 individuals had at least a palpable erythema by D4 to isoeugenol 1% pet. The majority of individuals allergic to isoeugenol were also intolerant of isoeugenyl acetate. Effective labelling of fragrance substances on consumer products will facilitate monitoring of exposure. |
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Bibliography: | ArticleID:COD272 ark:/67375/WNG-0ZZ66HMK-D istex:F4572F76F34018CC42BAE375540174F8273D6B90 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0105-1873 1600-0536 |
DOI: | 10.1111/j.1600-0536.1999.tb06160.x |