Divergent Immunomodulatory Effects of Extracts and Phenolic Compounds from the Fern Osmunda Japonica Thunb
Objective： To study possible immunobiological potential of Osmunda japonica Thunb. Methods： Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal ce...
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| Published in | Chinese journal of integrative medicine Vol. 19; no. 10; pp. 761 - 770 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.10.2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-0415 1993-0402 1993-0402 |
| DOI | 10.1007/s11655-013-1460-4 |
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| Abstract | Objective： To study possible immunobiological potential of Osmunda japonica Thunb. Methods： Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells （2 × 10_6/mL; 24 h culture）. Biosynthesis of nitric oxide （NO） was assayed by Griess reagent, production of prostaglandin E2 （PGE2） and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay. Resalts： The extracts activated dose dependently, with the onset at 2.5-5 μ mol/L concentrations, the high output NO production, and secretion of interferon-r, （IFN-r）, tumor necrosis factor-oL （TNF-α） and interleukin-1 （IL-1 13 ）. Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3,4-hydroxybenzaldehyde. In contrasts, the acetone-type phenolics 4-hydroxybenzalacetone and 3,4-hydroxybenzalacetone inhibited production of immune mediators including cytokines （TNF-α, IL-β, IL-6）, NO, and PGE2. The 3,4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The ICsoS estimates ranged within the interval of 5-10 μ mol/L. No signs of cytotoxicity were observed up to the 50 μ-mol/L concentration of the compounds. Coaclasiea： Phenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity. |
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| AbstractList | To study possible immunobiological potential of Osmunda japonica Thunb.
Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells (2×10(6)/mL; 24 h culture). Biosynthesis of nitric oxide (NO) was assayed by Griess reagent, production of prostaglandin E2 (PGE2) and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay.
The extracts activated dose dependently, with the onset at 2.5-5 μmol/L concentrations, the high output NO production, and secretion of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3,4-hydroxybenzaldehyde. In contrasts, the acetone-type phenolics 4-hydroxybenzalacetone and 3,4-hydroxybenzalacetone inhibited production of immune mediators including cytokines (TNF-α, IL-1β, IL-6), NO, and PGE2. The 3,4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The IC50s estimates ranged within the interval of 5-10 μmol/L. No signs of cytotoxicity were observed up to the 50 μmol/L concentration of the compounds.
Phenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity. Objective To study possible immunobiological potential of Osmunda japonica Thunb . Methods Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells (2×10 6 /mL; 24 h culture). Biosynthesis of nitric oxide (NO) was assayed by Griess reagent, production of prostaglandin E 2 (PGE 2 ) and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay. Results The extracts activated dose dependently, with the onset at 2.5–5 μmol/L concentrations, the high output NO production, and secretion of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3,4-hydroxybenzaldehyde. In contrasts, the acetone-type phenolics 4-hydroxybenzalacetone and 3,4-hydroxybenzalacetone inhibited production of immune mediators including cytokines (TNF-α, IL-1β, IL-6), NO, and PGE 2 . The 3,4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The IC 50 s estimates ranged within the interval of 5–10 μmol/L. No signs of cytotoxicity were observed up to the 50 μmol/L concentration of the compounds. Conclusion Phenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity. Objective： To study possible immunobiological potential of Osmunda japonica Thunb. Methods： Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells （2 × 10_6/mL; 24 h culture）. Biosynthesis of nitric oxide （NO） was assayed by Griess reagent, production of prostaglandin E2 （PGE2） and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay. Resalts： The extracts activated dose dependently, with the onset at 2.5-5 μ mol/L concentrations, the high output NO production, and secretion of interferon-r, （IFN-r）, tumor necrosis factor-oL （TNF-α） and interleukin-1 （IL-1 13 ）. Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3,4-hydroxybenzaldehyde. In contrasts, the acetone-type phenolics 4-hydroxybenzalacetone and 3,4-hydroxybenzalacetone inhibited production of immune mediators including cytokines （TNF-α, IL-β, IL-6）, NO, and PGE2. The 3,4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The ICsoS estimates ranged within the interval of 5-10 μ mol/L. No signs of cytotoxicity were observed up to the 50 μ-mol/L concentration of the compounds. Coaclasiea： Phenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity. To study possible immunobiological potential of Osmunda japonica Thunb.OBJECTIVETo study possible immunobiological potential of Osmunda japonica Thunb.Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells (2×10(6)/mL; 24 h culture). Biosynthesis of nitric oxide (NO) was assayed by Griess reagent, production of prostaglandin E2 (PGE2) and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay.METHODSImmunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells (2×10(6)/mL; 24 h culture). Biosynthesis of nitric oxide (NO) was assayed by Griess reagent, production of prostaglandin E2 (PGE2) and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay.The extracts activated dose dependently, with the onset at 2.5-5 μmol/L concentrations, the high output NO production, and secretion of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3,4-hydroxybenzaldehyde. In contrasts, the acetone-type phenolics 4-hydroxybenzalacetone and 3,4-hydroxybenzalacetone inhibited production of immune mediators including cytokines (TNF-α, IL-1β, IL-6), NO, and PGE2. The 3,4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The IC50s estimates ranged within the interval of 5-10 μmol/L. No signs of cytotoxicity were observed up to the 50 μmol/L concentration of the compounds.RESULTSThe extracts activated dose dependently, with the onset at 2.5-5 μmol/L concentrations, the high output NO production, and secretion of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3,4-hydroxybenzaldehyde. In contrasts, the acetone-type phenolics 4-hydroxybenzalacetone and 3,4-hydroxybenzalacetone inhibited production of immune mediators including cytokines (TNF-α, IL-1β, IL-6), NO, and PGE2. The 3,4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The IC50s estimates ranged within the interval of 5-10 μmol/L. No signs of cytotoxicity were observed up to the 50 μmol/L concentration of the compounds.Phenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity.CONCLUSIONPhenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity. |
| Author | 朱晓新 李玉洁 杨岚 张东 陈颖 EvaKmonickova 翁小刚 杨庆 Zdenek Zidek |
| AuthorAffiliation | Institute of Chinese Materia Medica, China Academyof Chinese Medical Sciences, Beijing （100700）, China; Department of Pharmacology, Institute of ExperimentalMedicine, Academy of Sciences of the Czech Republic, Prague（14200）, Czech Republic; Institute of Pharmacology andToxicology, Faculty of Medicine in Pilsen, Charles University,Pilsen （30166）, Czech Republic |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23918232$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1051/parasite/2003101p73 10.1021/np900027m 10.1006/phrs.1993.1110 10.4049/jimmunol.141.7.2407 10.1016/j.niox.2010.09.001 10.1126/science.7690156 10.1007/1-4020-5688-5_1 10.1111/j.1600-0625.2007.00603.x 10.1007/BF02973905 10.1016/j.phytochem.2010.01.002 10.1248/cpb.21.2336 10.1111/j.1476-5381.1994.tb14887.x 10.1016/S1567-5769(03)00117-6 10.1248/cpb.26.3071 10.1016/0952-7915(91)90079-G 10.1128/MMBR.59.4.533-547.1995 10.1248/cpb.38.2862 10.3177/jnsv.57.118 10.4049/jimmunol.145.12.4306 10.1007/s00403-009-0950-x 10.1016/j.phytochem.2004.08.007 10.1055/s-2007-981588 10.1021/bi00424a003 10.1016/j.jep.2004.12.031 10.1172/JCI116479 10.1111/j.1600-051X.1986.tb00876.x 10.1002/ijc.23161 10.1007/s10787-007-1603-3 10.1007/BF02974043 10.1016/j.phymed.2006.11.029 10.1248/cpb.53.625 10.1128/AEM.28.5.867-871.1974 10.1016/j.cbi.2006.10.010 |
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| Notes | Osmunda japonica L., extracts, phenolic compounds, cytokines, nitric oxide, prostaglandin E_2 ZHU Xiao-xin LI Yu-jie YANG Lan ZHANG Dong CHEN Ying Eva Kmonickova WENG Xiao-gang YANG Qing and Zdenek Zidek （1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing （100700）, China; 2. Department of Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague （14200）, Czech Republic; 3. Institute of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, Pilsen （30166）, Czech Republic） 11-4928/R Objective： To study possible immunobiological potential of Osmunda japonica Thunb. Methods： Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells （2 × 10_6/mL; 24 h culture）. Biosynthesis of nitric oxide （NO） was assayed by Griess reagent, production of prostaglandin E2 （PGE2） and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay. Resalts： The extracts activated dose dependently, with the onset at 2.5-5 μ mol/L concentrations, the high output NO production, and secretion of interferon-r, （IFN-r）, tumor necrosis factor-oL （TNF-α） and interleukin-1 （IL-1 13 ）. Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3,4-hydroxybenzaldehyde. In contrasts, the acetone-type phenolics 4-hydroxybenzalacetone and 3,4-hydroxybenzalacetone inhibited production of immune mediators including cytokines （TNF-α, IL-β, IL-6）, NO, and PGE2. The 3,4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The ICsoS estimates ranged within the interval of 5-10 μ mol/L. No signs of cytotoxicity were observed up to the 50 μ-mol/L concentration of the compounds. Coaclasiea： Phenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| Snippet | Objective： To study possible immunobiological potential of Osmunda japonica Thunb. Methods： Immunomodulatory effects of ethanol extracts prepared from... Objective To study possible immunobiological potential of Osmunda japonica Thunb . Methods Immunomodulatory effects of ethanol extracts prepared from rhizomes... To study possible immunobiological potential of Osmunda japonica Thunb. Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and... To study possible immunobiological potential of Osmunda japonica Thunb.OBJECTIVETo study possible immunobiological potential of Osmunda japonica... |
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| SubjectTerms | Animals Cell Survival - drug effects Cells, Cultured Dinoprostone - biosynthesis Female Ferns - chemistry Immunologic Factors - pharmacology Interferon-gamma - pharmacology Lipopolysaccharides - pharmacology Medicine Medicine & Public Health Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Original Article Peritoneum - cytology Peritoneum - drug effects Phenols - chemistry Phenols - isolation & purification Phenols - pharmacology Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Polymyxin B - pharmacology Proline - analogs & derivatives Proline - pharmacology Rats Rats, Wistar RNA, Messenger - genetics RNA, Messenger - metabolism Thiocarbamates - pharmacology TNF-α 乙醇提取物 免疫调节作用 白细胞介素-1 羟基苯甲醛 薇菜 酚类化合物 酶联免疫吸附试验 |
| Title | Divergent Immunomodulatory Effects of Extracts and Phenolic Compounds from the Fern Osmunda Japonica Thunb |
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